Results 41 to 50 of about 13,379 (221)

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Applicability of the National Comprehensive Cancer Network/Multinational Association of Supportive Care in Cancer Guidelines for Prevention and Management of Chemotherapy-Induced Nausea and Vomiting in Southeast Asia: A Consensus Statement. [PDF]

, 2017
A meeting of regional experts was convened in Manila, Philippines, to develop a resource-stratified chemotherapy-induced nausea and vomiting (CINV) management guideline. In patients treated with highly emetogenic chemotherapy in general clinical settings,
Abdullah, Matin M, Chan, Alexandre, Ishak, Wan Zamaniah B Wan, Kanesvaran, Ravindran, Ong-Cornel, Annielyn B, Villalon, Antonio H   +5 more
core   +2 more sources

CircRbfox1 Contributes to Colonic Hypersensitivity in Rats With Diabetes by Altering HuC Subcellular Localization to Regulate RBFOX1 Expression

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
circRbfox1 mediates diabetic colonic hypersensitivity by binding the RNA‐binding protein HuC, facilitating its nuclear translocation in T13‐L2 DRGs. This enhances transcription of the parent gene Rbfox1, culminating in increased expression of the L‐type calcium channel Cav1.3.
Shiyu Zhang, Ji Hu, Chendong Ni, Yilian Zhang, Jiahao Chen, Yajing Liu, Shufen Hu, Fuchao Zhang, Guang‐Yin Xu, Hong‐Hong Zhang   +9 more
wiley   +1 more source

Dynamics of heart rate variability in rats with streptozotocin-induced diabetes

Сахарный диабет, 2019
Background: Diabetes mellitus (DM) has a negative impact on all organs. This is due to insufficiency of blood supply and the disruption of the trophic function of the nervous system.
Maria P. Morozova, Svetlana A. Gavrilova, Evgeniy V. Ivanov, Anna M. Gorbacheva, Ekaterina M. Rzhavina, Aleksey K. Erdyakov, Zera N. Dzhemilova, Ekaterina V. Artemova, Alla Y. Tokmakova, Vladimir B. Koshelev, Gagik R. Galstyan   +10 more
doaj   +1 more source

GLP‐1 at the Metabolic–Cognitive Interface: Reward, Affect, and Memory

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
GLP‐1R signaling integrates metabolic state with neural circuits controlling reward, mood, and memory, acting as a metabolic‐cognitive interface. In reward pathways, it suppresses hedonic feeding and drug seeking; in affective circuits, sustained signaling promotes anxiolytic and antidepressant effects; and in the hippocampus, it enhances synaptic ...
Serena X. Gao, Léa Décarie‐Spain, Cindy Gu, Giulia Mazzini, Scott E. Kanoski, Tito Borner   +5 more
wiley   +1 more source

Secretome effect of adipose tissue-derived stem cells cultured two-dimensionally and three-dimensionally in mice with streptozocin induced type 1 diabetes

Current Research in Pharmacology and Drug Discovery, 2021
Aims: To analyze therapeutic potential of the conditioned medium from adipose tissue-derived stem cells (ASC) cultivated in 2D (CM-2D) and 3D (CM-3D) models, in mice with Type 1 diabetes (T1D) induced by streptozotocin.
Isabelle Dias, Daphne Pinheiro, Karina Ribeiro Silva, Ana Carolina Stumbo, Alessandra Thole, Erika Cortez, Laís de Carvalho, Simone Nunes Carvalho   +7 more
doaj   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Chemotherapy-related complications in the kidneys and collecting system: an imaging perspective [PDF]

, 2015
Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. The agents most commonly associated with chemotherapy-associated nephrotoxicity are methotrexate, semustine, streptozocin, mithramycin, and cisplatin.
Goodwin, Scott C., Gulati, Rajesh, Jia, Jemianne Bautista, Lall, Chandana, Lamba, Ramit, Tirkes, Temel   +5 more
core   +1 more source

Evaluating FABP5 as a Therapeutic Target for Pain Management

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background and Objective Fatty acid‐binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammatory, neuropathic and joint pain models. Genetic knockout or knockdown of FABP5 induces analgesia in select visceral and inflammatory pain models.
William Warren, Myles Osborn, Martin Kaczocha, Andrew Yates, Saoirse O'Sullivan   +4 more
wiley   +1 more source

Cinnamaldehyde attenuates streptozocin-induced diabetic osteoporosis in a rat model by modulating netrin-1/DCC-UNC5B signal transduction

Frontiers in Pharmacology
Background: Cinnamaldehyde (CMD) is a major functional component of Cinnamomum verum and has shown treatment effects against diverse bone diseases. This study aimed to assess the anti-diabetic osteoporosis (DOP) potential of diabetes mellitus (DM) and to
Songjie Ji, Songjie Ji, Bingjia Zhao, Yuan Gao, Jun Xie, Huijun Han, Qunli Wu, Dan Yang   +7 more
doaj   +1 more source