Results 41 to 50 of about 8,719 (217)
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret +5 more
wiley +1 more source
, 1983 Forty patients with metastatic colorectal carcinoma who had received no prior chemotherapy were entered onto a trial of methyl-CCNU, 5-fluorouracil, vincristine, and streptozocin (MOF-STREP). Ten of 40 (25%) responded.
D J Perry, M D Weltz, J Blom, W M Butler
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Current Research in Pharmacology and Drug Discovery, 2021 Aims: To analyze therapeutic potential of the conditioned medium from adipose tissue-derived stem cells (ASC) cultivated in 2D (CM-2D) and 3D (CM-3D) models, in mice with Type 1 diabetes (T1D) induced by streptozotocin.
Isabelle Dias +7 more
doaj +1 more source
, 1994 Diabetes mellitus was induced in 40 male C57BL6 mice by injection of a low dose of streptozocin (45 mg/kg body weight) on 5 consecutive days. Twenty four of the mice were immunosuppressed by administration of 1.5 mg FK506/kg body weight daily for 10, 15,
CHIEFFI, Gabriella +2 more
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Frontiers in PharmacologyBackground: Cinnamaldehyde (CMD) is a major functional component of Cinnamomum verum and has shown treatment effects against diverse bone diseases. This study aimed to assess the anti-diabetic osteoporosis (DOP) potential of diabetes mellitus (DM) and to
Songjie Ji +7 more
doaj +1 more source
GLP‐1 at the Metabolic–Cognitive Interface: Reward, Affect, and Memory
Comprehensive Physiology, Volume 16, Issue 2, April 2026.GLP‐1R signaling integrates metabolic state with neural circuits controlling reward, mood, and memory, acting as a metabolic‐cognitive interface. In reward pathways, it suppresses hedonic feeding and drug seeking; in affective circuits, sustained signaling promotes anxiolytic and antidepressant effects; and in the hippocampus, it enhances synaptic ...
Serena X. Gao +5 more
wiley +1 more source
Structural and mechanistic studies on the biosynthesis of streptozocin
, 2021 N-nitroso containing natural products, which contain the core structure −N−N=O, can act as both chemotherapeutics and as carcinogens due to their ability to alkylate DNA.
Henderson, Alyssa
core
Crystal Structure of Streptozocin
Analytical Sciences: X-ray Structure Analysis Online, 2003 The crystal belongs to space group P212121, and the cell dimensions are a = 8.5300(5), b = 11.4516(9) and c = 23.893(1)A. The final R value is 0.047. There are two crystallographically independent molecules in an asymmetric unit. The pyranose rings in both molecules take chair conformations. The nitrosourea moieties are planar.
HARAMURA, Masayuki +3 more
openaire +2 more sources
Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi +6 more
wiley +1 more source
, 2017 Background: Diabetes prevalence is estimated to increase annually. Numerous people use traditional medicine, such as India also considered as the diabetic capital in the world.
Sampath D. +7 more
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