Results 41 to 50 of about 8,779 (217)

Redefining the Role of Chemotherapy and Targeted Cytotoxic Delivery in Lung Neuroendocrine Tumors

Thoracic Cancer, Volume 17, Issue 16, August 2026.
Perioperative chemotherapy utility remains uncertain and lacks universal standardization. Platinum/etoposide shows suboptimal efficacy in lung NET (neuroendocrine tumors); oral alkylators (temozolomide) alone or in combination (e.g., with capecitabine), and cabozantinib offer promising disease control.
Alice Laffi, Giuseppe Lamberti, Anna La Salvia   +2 more
wiley   +1 more source

Alterations of islet microvasculature in mice treated with low-dose streptozocin [PDF]

, 1992
Islet capillary area was followed daily in mice after treatment with low-dose streptozocin (LDS), in order to elucidate the exact period during which the insular vascular bed undergoes a significant reduction.
CHIEFFI, Gabriella, G. Chieffi-Baccari, PAPACCIO, Gianpaolo, G. Papaccio   +3 more
core   +1 more source

Biomimetic MCC950‐loaded cerium‐layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin‐induced mice

British Journal of Pharmacology, Volume 183, Issue 16, Page 4919-4938, August 2026.
The CLMBM nanoparticle (NP) system demonstrates strong and targeted anti‐ROS, antiapoptotic and anti‐inflammatory properties within the pancreas, thereby inhibiting the onset and progression of type 1 diabetes. Background and Purpose The destruction of β‐cells in type 1 diabetes is driven by signalling cascades that ultimately lead to cell apoptosis ...
Huiwen Pang, Zhuo Chen, Youzhi Wu, Thanh‐Truc Nguyen, Jingjing Wang, David M. Klyne, Zhi Ping Xu, Chen Chen, Alan Rowan, Felicity Y. Han   +9 more
wiley   +1 more source

Anti-allodynic and anti-hyperalgesic effects of ceftriaxone in streptozocin-induced diabetic rats [PDF]

, 2011
Glutamate is the principal excitatory neurotransmitter in the central nervous system. Recent evidence suggests that beta lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.
Buldum, Dilek, Guven, Rabia, Oltulu, Cagatay, Rabia Guven, Cagatay Oltulu, Dilek Buldum, Ulugol, Ahmet, Ozgur Gunduz, Ahmet Ulugol, Gunduz, Ozgur   +9 more
core   +1 more source

Estradiol Replacement Modulates Synaptic Transmission‐Related Proteins in the Hippocampus of Ovariectomized Rats: An Exploratory Proteomic Approach

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
The estrogen deficiency in the hippocampus influences cognitive functions and control of food intake. Hippocampi of female rats, either control or ovariectomized, with or without estrogen replacement, were submitted to LC–MS/MS and analysis of pathway‐based functional roles of proteins affected by estrogen deficiency and replacement.
Amanda Paula Pedroso, Adriana Pereira Souza, Guilherme Araújo Câmara, Meira Maria Forcellini Machado, Valter Tadeu Boldarine, Lila Missae Oyama, Mônica Marques Telles, Alexandre Keiji Tashima, Eliane Beraldi Ribeiro   +8 more
wiley   +1 more source

Influence of streptozocin-induced diabetes on reductive metabolism of acetohexamide in rat liver [PDF]

, 1989
Streptozocin-induced diabetes significantly decreased acetohexamide reductase activity of 10 000 g supernatant of liver homogenates from both male and female rats.
Yuichiro Kojima, Masaki Otagiri, Yorishige Imamura   +2 more
core   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, Volume 13, Issue 41, 22 July 2026.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Determination of antihyperglycemic activity of ethanolic crude leaf extract of cassia auriculata in the streptozocin induced male wistar albino rats [PDF]

, 2022
Cassia auriculata is used extensively in the indigenous system of medicine as an anti-diabetic agent. The current investigation focuses on determination of antihyperglycemic activity of ethanolic crude leaf extract of cassia auriculata (CA) in the ...
Venkatesan, Rantham Subramaniam, Shanmugam, Hemalatha, Venkatesan, R. S. (Rantham), Shanmugam, H. (Hemalatha)   +3 more
core   +2 more sources

Dynamics of heart rate variability in rats with streptozotocin-induced diabetes

Сахарный диабет, 2019
Background: Diabetes mellitus (DM) has a negative impact on all organs. This is due to insufficiency of blood supply and the disruption of the trophic function of the nervous system.
Maria P. Morozova, Svetlana A. Gavrilova, Evgeniy V. Ivanov, Anna M. Gorbacheva, Ekaterina M. Rzhavina, Aleksey K. Erdyakov, Zera N. Dzhemilova, Ekaterina V. Artemova, Alla Y. Tokmakova, Vladimir B. Koshelev, Gagik R. Galstyan   +10 more
doaj   +1 more source

Secretome effect of adipose tissue-derived stem cells cultured two-dimensionally and three-dimensionally in mice with streptozocin induced type 1 diabetes

Current Research in Pharmacology and Drug Discovery, 2021
Aims: To analyze therapeutic potential of the conditioned medium from adipose tissue-derived stem cells (ASC) cultivated in 2D (CM-2D) and 3D (CM-3D) models, in mice with Type 1 diabetes (T1D) induced by streptozotocin.
Isabelle Dias, Daphne Pinheiro, Karina Ribeiro Silva, Ana Carolina Stumbo, Alessandra Thole, Erika Cortez, Laís de Carvalho, Simone Nunes Carvalho   +7 more
doaj   +1 more source