Results 91 to 100 of about 181,208 (343)

Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2015
Chronic hyperglycemia and the corresponding glucotoxicity are the main pathogenic mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced diabetic animal models are useful platforms for the understanding of β cell glucotoxicity in ...
Jinzi Wu, Liang-Jun Yan
semanticscholar   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds

Advanced Science, EarlyView.
The Polyphenol+PDGF‐BB scaffold fabrication (Panel A) and its dual wound healing effects (Panel B: anti‐inflammation and accelerated tissue remodeling). ABSTRACT Chronic diabetic wounds suffer from dysfunctional repair programs due to accumulated advanced glycation end products (AGEs) and persistent inflammation in hyperglycemic microenvironments ...
Lei Yi, Wanqian Li, Ying Duanmu, Zihan Zhang, Shixuan Chen, Shichu Xiao, Lei Du, Miaomiao Wei   +7 more
wiley   +1 more source

An in vivo and in vitro investigation of the effect of Aloe vera gel ethanolic extract using animal model with diabetic foot ulcer

Journal of Pharmacy and Bioallied Sciences, 2014
Aim: To examine the preventive effect of Aloe vera gel ethanolic extract using diabetic foot ulcer (DFUs) protocol in Wistar rats. Materials and Methods: Male Wistar rats were divided into untreated control (Group I), untreated DFUs (Group II), DFUs ...
Mohan Daburkar, Vikram Lohar, Arvind Singh Rathore, Pravin Bhutada, Shrikant Tangadpaliwar   +4 more
doaj   +1 more source

Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid [PDF]

, 2013
Methanol extracts of the roots of B. brevissima and B. parkeriana were examined for antidiabetic and antimicrobial activities. Six compounds i.e berberine, 8-oxo-berberine, dehydrocheilanthifoline, columbamine, jatrorrhizine and glutamic acid were ...
Ali, Saqib, Almazeb, Muhammad, Clements, Carol, Ferro, Valerie, Gray, Alexander, Igoli, John, Khan, M Rafiullah, Rashid, Mamoon-Ur, Semaan, Dima, Shah, Syed Qaisar   +9 more
core   +1 more source

The Antidiabetic Effect of Low Doses of Moringa oleifera Lam. Seeds on Streptozotocin Induced Diabetes and Diabetic Nephropathy in Male Rats

BioMed Research International, 2015
The antidiabetic activity of two low doses of Moringa seed powder (50 and 100 mg/kg body weight, in the diet) on streptozotocin (STZ) induced diabetes male rats was investigated. Forty rats were divided into four groups.
A. L. Al-Malki, H. E. El Rabey
semanticscholar   +1 more source

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

Advanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao, Zhihao Wang, Shasha Tang, Yuan Fang, Guiling Yu, Xiaoting Qiu, Lingxue Niu, Tao Yan, Xingwan Liu, Xiaoding Ma, Deqiang Kong, Yang Zhou, Ningzi Guan, Jinzhong Tian, Meiyan Wang, Haifeng Ye, Fengfeng Cai   +16 more
wiley   +1 more source

Effect of Pleurotus fossulatus Aqueous Extract on Biochemical Properties of Liver and Kidney in Streptozotocin-Induced Diabetic Rat

Diabetes, Metabolic Syndrome and Obesity, 2020
Sushil Dubey, Chandrabhan Yadav, Anand Bajpeyee, Mohan P Singh Centre of Biotechnology, University of Allahabad, Prayagraj, Uttar Pradesh, IndiaCorrespondence: Mohan P SinghCoordinator, Centre of Biotechnology Institute of Interdisciplinary Studies (IIDS)
Dubey S, Yadav C, Bajpeyee A, Singh MP
doaj  

Peculiarities of disturbances of the functional renal state in the early period of experimental diabetes mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2017
Background. The purpose of our research was a comparative analysis of specificity and severity of kidney dysfunction in the early period of alloxan- and streptozotocin-induced diabetes mellitus. Materials and methods. The article presents data concerning
T.M. Boychuk, О.А. Olenovych, M.I. Grytsiuk, A.I. Gozhenko   +3 more
doaj   +1 more source

Mode of Action of Streptozotocin [PDF]

Journal of Bacteriology, 1971
Streptozotocin induces rapid degradation of deoxyribonucleic acid (DNA) in actively dividing or resting Bacillus subtilis cells. Difference spectroscopy showed that the antibiotic interacts specifically with cytosine containing mononucleotides in vitro. This interference occurs only within the very narrow
openaire   +2 more sources