Results 191 to 200 of about 151,903 (303)

Nicotinamide mononucleotide alleviates the streptozotocin-mediated ferroptosis of islet β-cells via the Nrf2/GPX4 pathway. [PDF]

Braz J Med Biol Res
Lu D, Huang J, Meng J, Luo J, Huang X.
europepmc   +1 more source

Mechanical sensitization of sensory afferents after passive transfer of fibromyalgia IgG

The Journal of Physiology, EarlyView.
Abstract figure legend In addition to widespread pain and fatigue, people with fibromyalgia (FM) experience sensory abnormalities and report lingering, painful sensations after touch or mechanical probing of the skin. Administration of IgG purified from FM patients to mice transfers symptoms and signs of FM.
Mathilde R. Israel, Nisha Vastani, Clive Gentry, Andreas Goebel, Stuart Bevan, David A. Andersson   +5 more
wiley   +1 more source

Changes in Expression of Syndecans and Heparan Sulfate Biosynthesis Enzymes in Short-Term Streptozotocin-Induced Diabetic Rat Kidneys. [PDF]

Cells
Čujić T, Racetin A, Filipović N, Kostić S, Kelam N, Todorović P, Vukojević K.   +6 more
europepmc   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Myostatin‐dependent detrusor remodelling mediates contractility impairment in diabetic rats’ bladder – a maximal elastance analysis

The Journal of Physiology, EarlyView.
Abstract figure legend In the muscular layer of long‐standing diabetic bladders increased myostatin expression promotes tissue remodelling by reducing the muscle‐to‐collagen ratio, ultimately diminishing bladder contractility. Maximal elastance – defined as the slope of the end‐emission pressure–volume relationship (EPR), derived from the regression ...
Cheng‐Yuan Lai, Hui‐Hsuan Lau, Ming‐Chun Hsieh, Hsien‐Yu Peng, Dylan Chou, Tsung‐Hsien Su, Tzer‐Bin Lin   +6 more
wiley   +1 more source

Protective Effects of a Cissus quadrangularis Stem Peel Ash Derived Salt Against Streptozotocin Induced Cellular Injury in SH‐SY5Y Cells

Applied Research, Volume 5, Issue 5, October 2026.
Cissus quadrangularis stem peel‐derived bio salt protects SH‐SY5Y neuroblastoma cells against streptozotocin‐induced neurotoxicity by reducing oxidative stress, suppressing apoptosis, and improving cell viability. These findings highlight its potential as a natural neuroprotective agent for neurodegenerative disorders.
Panimalar Thirupathi Brindhavanam, Ramasamy Mahadevi, Veeran Sethuraman, Manickam Rajkumar, Kavitha Ramamoorthy   +4 more
wiley   +1 more source

Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond, Ronny Amamoo, Fapianey J. Alexandre, Sewedo B. Ajisegiri, Menaka C. Thounaojam, Pamela M. Martin, Ravirajsinh N. Jadeja   +6 more
wiley   +1 more source

Single crystal X-ray structurally characterized dual functioning oxovanadium(iv) complex of amide-imine derivative: studies on anti-diabetic and Th(iv) recognition properties. [PDF]

RSC Adv
Mandal P, Maji S, Barik S, Patra M, Biswas SJ, Das D.   +5 more
europepmc   +1 more source

Amyloid‐Forming Amylin Secreted by the Pancreas Promotes Hypoxia‐Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Human amylin is secreted from the pancreas of HIP rats and is amyloidogenic, forming aggregates systemically. In comparison with age‐matched control (WT), hyperglycemic (UCD) and amylin knockout rats (AKO), HIP rats showed increased hypoxia‐inducible factors (HIF‐1/2) in heart and liver, alongside alterations in mitochondrial electron transfer system ...
Alice E. Knapton, Nirmal Verma, Deepak Kotiya, Alice P. Sowton, Benjamin D. Thackray, Lorenz M. W. Holzner, Paula M. Darwin, Sanda Despa, Florin Despa, Andrew J. Murray   +9 more
wiley   +1 more source

Zingerone alleviates diabetic nephropathy by interrupting the ER stress-inflammation-apoptosis cascade in streptozotocin-induced diabetic mice. [PDF]

Braz J Med Biol Res
Ke B, Xiong X, Wang C, Feng X, Yan H, Wang W, Xu G.   +6 more
europepmc   +1 more source