Journal of Diabetes, Volume 18, Issue 5, May 2026.This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li +5 more
wiley +1 more source
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret +5 more
wiley +1 more source
RETRACTED: Nazir et al. Curative Effect of Catechin Isolated from <i>Elaeagnus Umbellata</i> Thunb. Berries for Diabetes and Related Complications in Streptozotocin-Induced Diabetic Rats Model. <i>Molecules</i> 2021, <i>26</i>, 137. [PDF]
MoleculesNazir N +4 more
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 9, Page 1901-1919, May 2026.Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao +12 more
wiley +1 more source
Intracerebroventricular streptozotocin-induced animal model of Alzheimer's disease: revealing dose optimization, administration regimen, and molecular pathways. [PDF]
Lab Anim ResMore SA +6 more
europepmc +1 more source
Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes
British Journal of Pharmacology, Volume 183, Issue 9, Page 2099-2122, May 2026.Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata +13 more
wiley +1 more source
Rapid improvement of renal microcirculatory homeostasis by liraglutide following diabetes induction
Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4066-4081, May 2026.Abstract Aims Renal microvascular dysfunction is a central driver of diabetic kidney disease, yet the potential for rapid therapeutic reversal remains obscure. We investigated the effect of short‐term liraglutide on early changes in the renal microcirculation post‐induction of diabetes.
Yuan Li +8 more
wiley +1 more source
Betanin Modulates the Leptin-Adiponectin Axis and Improves Glycemic Control in a High-Fat Diet and Streptozotocin-Induced Rat Model of Type 2 Diabetes. [PDF]
CureusAgrawal S +5 more
europepmc +1 more source
Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice.
Brain Research, 2016 W. Oliveira +8 more
semanticscholar +1 more source
Genes to Cells, Volume 31, Issue 3, May 2026.The effects of intraocular administration of neutralizing antibodies against VEGFA, ANG‐2, or bispecific to these two factors on pathological findings were examined in the oxygen‐induced retinopathy (OIR) mouse model. The antibody to VEGFA or ANG‐2 attenuated oxygen‐induced neovascularization and inflammation, and the bispecific antibody more ...
Hirokazu Oohashi +8 more
wiley +1 more source