Results 191 to 200 of about 56,294 (245)

Streptozotocin- and alloxan-diabetes in mice

European Journal of Pharmacology, 1969
Abstract In non-fasted albino (NMRI) mice intravenous diabetogenic doses were 200 mg/kg body weight of streptozotocin or 70 mg/kg of alloxan monohydrate. Differences in diabetes development were as follows. Maximal blood glucose levels during the phase of acute hyperglycaemia were observed 120 min after streptozotocin and 45 min after alloxan ...
Claus Rerup
exaly   +3 more sources

Genotoxicity of Streptozotocin

Mutation Research/Reviews in Mutation Research, 2002
Streptozotocin (Streptozocin, STZ, CAS No. 18883-66-4) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals through its toxic effects on pancreatic beta cells.
Alejandro D, Bolzán, Martha S, Bianchi
openaire   +2 more sources

Streptozotocin for Insulinoma

Annals of Internal Medicine, 1971
Excerpt To the editor: Schriebman, Goransky De Koliren, and Arky (Ann Intern Med74:399-403, 1971) reported on a patient with metastatic insulinoma who had been treated with streptozotocin.
E, Piroska, E, Kollin
openaire   +2 more sources

Studies on streptozotocin diabetes

Diabetes, 1976
Both alloxan and streptozotocin produce β-cell necrosis in the rat. Previous studies have shown protection against alloxan toxicity by D-glucose, D-mannose, and the nonmetabolized analogue 3-0-methyl-D-glucose and removal of this protective effect by D-mannoheptulose. The effect of several agents (i.v.
O P, Ganda, A A, Rossini, A A, Like
openaire   +2 more sources

Streptozotocin and Metastatic Insulinoma

Annals of Internal Medicine, 1971
Excerpt The Chemotherapy Program of the National Cancer Institute has among its major goals the development of new antineoplastic drugs.
S K, Carter, L, Broder, M, Friedman
openaire   +2 more sources

Mutagenic activity of streptozotocin

Mutation Research, 1968
Abstract Streptozotocin plus “cofactor” has been shown to be mutagenic for histidine requiring Salmonella typhimurium strains. The cofactor has been shown to be nonessential to this activity. Revertant frequency data presented indicate that streptozotocin and N-nitrosoguanidine have comparable activity.
S M, Kolbye, M S, Legator
openaire   +2 more sources

Streptozotocin is not a Spontaneous NO Donor

Free Radical Research, 1996
The reaction of streptozotocin with oxymyoglobin was analyzed and compared with results using various compounds that spontaneously generate nitric oxide in solution.
K D, Kröncke, V, Kolb-Bachofen
openaire   +2 more sources

Hyperlipoproteinemia in Streptozotocin-treated Rats

Diabetes, 1976
In order to study hyperlipidemia in diabetes mellitus, rats were made diabetic by administration of streptozotocin and the optimal conditions for production of severe and persistent hyperlipoprotenemia determined. Two groups of rats were compared: rats fed sucrose-rich diets and rats fed laboratory chow.
H, Bar-On, P S, Roheim, H A, Eder
openaire   +2 more sources

Hypercalcemia and Streptozotocin

Annals of Internal Medicine, 1974
Excerpt To the editor: I read with interest the article, "Islet Cell Tumors: Current Concepts and Management," by Schein and associates (Ann Intern Med79:239-257, 1973).
ERIC A. LARYEA, ROBERT BRODRICK, ROBERT HIDVEGI   +2 more
openaire   +1 more source

Modifizierte Streptozotocine

Helvetica Chimica Acta, 1974
Gemäss Formelschema werden die Synthesen modifizierter Streptozotocine der Struktur 5 aus N‐Nitroso‐carbamoylaziden 3 und D‐Glucosamin, ihre α‐1,3,4,6‐Tetra‐O‐acetyl‐Derivate 6 und die vergleichsweise aus 1,3,4,6‐Tetra‐O‐acetyl‐β‐D‐glucosamin 7 hergestellten zu 6 anomeren β‐Tetraacetyl‐Derivate 9, beschrieben.
Arthur Meier, Fred Stoos, Dante Martin, Gürol Büyük, Emil Hardegger   +4 more
openaire   +1 more source