Results 271 to 280 of about 181,208 (343)

A practical guide for induction of type-2 diabetes in rat: Incorporating a high-fat diet and streptozotocin

Biomedicine and Pharmacotherapy, 2017
Sevda Gheibi, Khosrow Kashfi, Asghar Ghasemi   +2 more
exaly   +2 more sources

Streptozotocin as a tool for induction of rat models of diabetes: a practical guide

EXCLI Journal : Experimental and Clinical Sciences, 2023
Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type 1 and type 2 diabetes. Despite ~60 years of using STZ in animal diabetes research, some prevailing views about STZ preparation and use are not supported by ...
A. Ghasemi, S. Jeddi
semanticscholar   +1 more source

Genotoxicity of Streptozotocin

Mutation Research/Reviews in Mutation Research, 2002
Streptozotocin (Streptozocin, STZ, CAS No. 18883-66-4) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals through its toxic effects on pancreatic beta cells.
Alejandro D, Bolzán, Martha S, Bianchi
openaire   +2 more sources

Streptozotocin for Insulinoma

Annals of Internal Medicine, 1971
Excerpt To the editor: Schriebman, Goransky De Koliren, and Arky (Ann Intern Med74:399-403, 1971) reported on a patient with metastatic insulinoma who had been treated with streptozotocin.
E, Piroska, E, Kollin
openaire   +2 more sources

Studies on streptozotocin diabetes

Diabetes, 1976
Both alloxan and streptozotocin produce β-cell necrosis in the rat. Previous studies have shown protection against alloxan toxicity by D-glucose, D-mannose, and the nonmetabolized analogue 3-0-methyl-D-glucose and removal of this protective effect by D-mannoheptulose. The effect of several agents (i.v.
O P, Ganda, A A, Rossini, A A, Like
openaire   +2 more sources

Modifizierte Streptozotocine

Helvetica Chimica Acta, 1974
Gemäss Formelschema werden die Synthesen modifizierter Streptozotocine der Struktur 5 aus N‐Nitroso‐carbamoylaziden 3 und D‐Glucosamin, ihre α‐1,3,4,6‐Tetra‐O‐acetyl‐Derivate 6 und die vergleichsweise aus 1,3,4,6‐Tetra‐O‐acetyl‐β‐D‐glucosamin 7 hergestellten zu 6 anomeren β‐Tetraacetyl‐Derivate 9, beschrieben.
Arthur Meier, Fred Stoos, Dante Martin, Gürol Büyük, Emil Hardegger   +4 more
openaire   +1 more source

Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats

Toxicology Mechanisms and Methods, 2019
The present study investigated the protective effect of hesperidin on carbohydrate metabolizing enzymes in streptozotocin-induced diabetic rats. Hesperidin was administered to streptozotocin-induced (40 mg/kg b.w.) diabetic rats at different dosages of ...
S. R, Nandhakumar E, Haseena Banu H
semanticscholar   +1 more source

Therapeutic Effect of Okra (Abelmoschus esculentus Moench) Pods Extract on Streptozotocin-Induced Type-2 Diabetic Mice

Research Journal of Pharmacy and Technology, 2019
The aims of this study were to determine the effect of various fractions of okra pods extract (VOPE) to the changes of fasting blood glucose, serum insulin, and GLUT4 density on streptozotocin-induced type-2 diabetic mice.
A. A. Zuraidah, D. Winarni, H. Punnapayak, W. Darmanto   +3 more
semanticscholar   +1 more source

Protective effect of daidzein against streptozotocin‐induced Alzheimer's disease via improving cognitive dysfunction and oxidative stress in rat model

Journal of biochemical and molecular toxicology, 2019
Oxidative stress is performing an essential role in developing Alzheimer's disease (AD), and age‐related disorder and other neurodegenerative diseases.
Jie Wei, Fenggang Yang, Chuanbao Gong, Xingyuan Shi, Guangliang Wang   +4 more
semanticscholar   +1 more source