Results 131 to 140 of about 1,971,553 (284)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Physiological Stress

, 2015
Die Stammzellforschung im Kontext regenerativer Maßnahmen, stellt einen vielversprechenden Ansatz dar, um einer alternden Bevölkerungsstruktur in Europa die Aussicht auf gesundes Altern zu ermöglichen. Das Forschungsziel dieses Projektes beruht darauf, molekulare Mechanismen der osteogenen Differenzierung von adulten mesenchymalen Stammzellen besser zu
openaire   +1 more source

Impact of Teleworking on Work‐Related and Home‐Related Stress at During the First Global Lockdown–The International COVISTRESS Study

Brain and Behavior
Background The initial lockdown during the pandemic of COVID‐19 led to adjustments in working conditions, including extensive use of telecommuting whenever possible, putatively influencing both work‐related and home‐related stress. Objectives Our aim was
Sébastien Couarraze, Guillaume Decormeille, Louis Delamarre, Fouad Marhar, Karen Gbaglo, Raimundo Avilès Dorlhiac, Mickael Berthon, Andy Su‐I Liu, Samuel Antunes, Bruno Pereira, Julien S Baker, Morteza Charkhabi, Ukadike C Ugbolue, Reza Bagheri, José J. Gil‐Cosano, Marek Zak, The COVISTRESS Network, Maëlys Clinchamps, Frédéric Dutheil   +18 more
doaj   +1 more source

Investigation of the relationship between university students’ attentional impulsivity levels and psychological and physiological stress responses

Archives of Medical Science
Introduction The purpose of this study is to investigate the relationship between attentional impulsivity levels and physiological and psychological stress responses of university students.
Burcu Köksal
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Exploring Physiological and Nonphysiological Responses of Sun-Induced Chlorophyll Fluorescence to Different Levels of Water Stress in Winter Wheat

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Sun-induced chlorophyll fluorescence (SIF) has recently been used for the early detection of plant stress. The response of SIF to water stress is complicated by the combination of physiological and nonphysiological dynamics in SIF variations and has not ...
Jingyu Lin, Litao Zhou, Jianjun Wu
doaj   +1 more source

Relationship between Cognitive Functions and Hormones [PDF]

, 2013
Stress has been implicated by recent research to significantly contribute towards many cognitive and physiological deficiencies. One of the most popular topics of study is the effect of stress on inhibition, the all-or-none decision about an action or ...
Miao, Daniel C.
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Stress and productivity patterns of interrupted, synergistic, and antagonistic office activities. [PDF]

, 2019
We describe a controlled experiment, aiming to study productivity and stress effects of email interruptions and activity interactions in the modern office. The measurement set includes multimodal data for n = 63 knowledge workers who volunteered for this
Akbar, Fatema, Buddharaju, Pradeep, Gao, Ge, Gutierrez-Osuna, Ricardo, Mark, Gloria, Pavlidis, Ioannis, Silva, Dennis Rodrigo Da Cunha, Wesley, Amanveer, Zaman, Shaila   +8 more
core   +1 more source