Results 61 to 70 of about 697,108 (267)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

On Prediction of 3d Stress State in Elastic Shell by Higher-order Shell Formulations [PDF]

, 2008
In this work we study the accuracy of modem higher-order shell finite element formulations in computation of 3d stress state in elastic shells. In that sense we compare three higher-order shell models: (i) with seven dislacement-like kinematic parameters,
Brank, Boštjan, Ibrahimbegović, Adnan, Bohinc, Uroš   +2 more
core  

Strain-Stress State of Wood During Drying Process

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2013
The paper proposes theoretical and experimental methods for investigation of strain-stress state of wood and lumber saw-timbers in the process of heated-air drying.
V. A. Sychevsky
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Stress Path Dependence of Mechanical Properties of Saturated Soft Loess and its Simulation

Taiyuan Ligong Daxue xuebao
[Purposes] The saturated soft loess formed by the rise of groundwater level is mostly in a soft plastic and flow plastic state, with engineering geological characteristics of high water content, high compression, and low bearing capacity.
LI Shixiong, ZHANG Dengfei, ZHANG Xiaohui, CHEN Hanjiang, WANG Yonghua   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Relaxation of thermal stress by dislocation motion in passivated metal interconnects [PDF]

, 2004
The development and relaxation of stress in metal interconnects strained by their surroundings (substrate and passivation layers) is predicted by a discrete dislocation analysis.
Giessen, Erik van der,, Needleman, Alan,, Van der Giessen, E, Erik Van der Giessen, Alan Needleman, Van der Giessen, E; id_orcid, Nicola, Lucia,, Nicola, L, Needleman, A, Lucia Nicola   +9 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Stress-Strain State of a Cylindrical Shell of a Tunnel Using Construction Stage Analysis

, 2019
The work is aimed at research of the stress-strain state of a cylindrical shell of a tunnel using the non-linear static analysis and construction stage analysis. Research is carried out on the example of determining the stress-strain state of the tubing (
Sergey B. Kosytsyn, Vladimir Y. Akulich
core   +1 more source