Results 51 to 60 of about 970,478 (306)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Unloaing and re-loading features of pre-strained steel at low temperature [PDF]
, 2013 In the present work the response of medium carbon steel is investigated experimentally and information on the features of initial loading, unloading, re-loading and inverse loading processes is collected.
Akiyama, Masayoshi, Dongdong, Li
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Stress-strain synchronization for high strain rate tests on brittle composites [PDF]
, 2018 Nowadays, many researchers develop rate-dependent composite material models for application in dynamic simulations. Ideally, full stress-strain curves at a wide range of strain rates are available for identification of the different parameters of these ...
Garoz Gómez, David +6 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Yantu gongcheng xuebaoThe tightness and stability of compressed air energy storage (CAES) gas reservoir is the basis to ensure the safe operation of power station. There are many factors affecting the mechanics of gas reservoir and its mechanics characteristics are complex ...
WAN Fa 1, 3, JIANG Zhongming 1, 2, LIAO Junhui 1, LI Haifeng 3
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Finite Element Analysis of Stress-Strain between Human Head and Headrest of Office Chair
Journal of Mechanical EngineeringThis study employs finite element analysis to evaluate the influence of office chair headrest curvature and inclination angle on head-headrest interaction.
Weikang Li +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source