Results 51 to 60 of about 32,745 (216)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Simulation analysis of stress-strain performance for a lightweight X-ray pulsar detection telescope frame structure

Frontiers in Astronomy and Space Sciences
With the continuous deepening of human exploration of the universe, space telescopes have emerged as pivotal tools for obtaining information about celestial bodies and their evolutionary principles.
Qingyong Zhou, Qingyong Zhou, Zhiqiang Huang, Bin Xu, Yaohu Lei, Jianguo Lei, Hang Zhao, Chaojing Ye, Likuan Zhu   +8 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Structural Performance of uPVC Confined Concrete Equivalent Cylinders Under Axial Compression Loads

Buildings, 2019
There is always a need for more durable, ductile, and robust materials for buildings, bridges, and other infrastructure due to the drawbacks of existing construction materials.
Abraham Mengesha Woldemariam, Walter O. Oyawa, Timothy Nyomboi   +2 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Influence of ultrasonic vibration on tensile properties and dislocation distribution of titanium foil

Cailiao gongcheng, 2019
The plastic deformation with respect to dislocation distribution of titanium foil under ultrasonic vibration was studied. The influencing rule of different ultrasonic vibration modes on the stress-strain,elongation and dislocation distribution of ...
JIANG Shao-song, YANG Tian-hao, SUN Hong-yu, HE Yu-shi, LU Zhen, WANG Rui-zhuo   +5 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Molecular Dynamics Simulation of the Dynamic Mechanical Behavior of FeNiCrMn High-Entropy Alloy

Nanomaterials
High-entropy alloys (HEAs) exhibit excellent properties such as high strength, good ductility, superior corrosion resistance, and thermal stability, making them highly promising for applications in the aerospace, energy, and automotive industries.
Haorui Liu, Nana Yang, Shu Xiao, Hu Zhang, Sheng Zhao, Kai Ma, Ning Mi   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Performance of Concrete Confined with a Jute–Polyester Hybrid Fiber Reinforced Polymer Composite: A Novel Strengthening Technique

Fibers, 2019
The strengthening and rehabilitation of concrete members is an important issue which arises worldwide. Carbon, aramid and glass fiber reinforced polymer (FRP) composites are mainly used for strengthening and rehabilitation. However, its use is limited on
Nauman Wahab, Penjit Srinophakun, Qudeer Hussain, Preeda Chaimahawan   +3 more
doaj   +1 more source