Results 51 to 60 of about 4,438,120 (290)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Work stress and risk of cancer: meta-analysis of 5700 incident cancer events in 116 000 European men and women [PDF]

, 2012
Objective To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers.Design Meta-analysis of pooled prospective individual ...
Burr, Herman,, Westerlund, Hugo,, Magnusson Hanson, Linda L, Vaananen, Ari,, Ferrie, Jane, E, Nyberg, Solja T, Consortium, IPD-Work, Nordin, Maria,, Virtanen, M., Steptoe, A., Nyberg, S.T., Bouillon, K., Bouillon, Kim,, Dragano, Nico, Knutsson, Anders,, Koskenvuo, Markku, Hanson, L.L.M., Nielsen, Martin ,, Nielsen, Martin,, Ferrie, Jane E.,, Houtman, Irene L., Nyberg, Solja, T, Madsen, Ida, E H, Magnusson Hanson, Linda ,, Westerholm, Peter,, Magnusson Hanson, Linda,, Houtman, Irene, L, Marmot, Michael, G, Hooftman, Wendela,, Borritz, Marianne,, Väänänen, Ari, Burr, Herman, Marmot, Michael G.,, Geuskens, Goedele A.,, Kouvonen, A., Hooftman, Wendela E, Oksanen, Tuula, Geuskens, Goedele, A, Theorell, T., Westerlund, Hugo, Pentti, J., Theorell, T�res, Dragano, N., Suominen, Sakari,, Ferrie, Jane,, Kouvonen, Anne,, Madsen, Ida,, Theorell, Töres, Knutsson, Anders, Virtanen, Marianna, Salo, Paula, Madsen, Ida E. H., Fransson, Eleonor I.,, Fransson, E.I., Houtman, I.L.D., Salo, Paula,, Fransson, Eleonor, I, Bouillon, Kim, Geuskens, Goedele,, Nordin, Maria, Marmot, M.G., Nyberg, Solja ,, Joensuu, Matti, Bonenfant, S�bastien, Marmot, Michael G., Goldberg, M., Madsen, Ida ,, Vaaanen, A., Hooftman, Wendela E., Nielsen, Martin L.,, Hamer, Mark, Batty, George David, Goldberg, Marcel,, Vahtera, Jussi, Nyberg, Solja T., Rugulies, Reiner Ernst, Rugulies, Reiner, Hamer, Mark,, Kivim�ki, Mika, Bonenfant, S., Westerholm, P., Joensuu, M., Koskinen, A., Borritz, Marianne, Nielsen, Martin L, Koskinen, Aki,, Bjorner, Jakob,, Heikkil�, Katriina, Fransson, Eleonor,, Magnusson Hanson, Linda L.,, Fransson, Eleonor I, Batty, G. David,, Magnusson, Linda L.,, Kouvonen, Anne, Madsen, Ida EH, Pentti, Jaana, Magnusson Hanson, Linda, L, IPD Work Consortium, Hooftman, Wendela E.,, Nielsen, M.L., Marmot, Michael ,, Singh-Manoux, A., Bonenfant, Sébastien, IPD-Work Consortium, Madsen, Ida E H, Bjorner, Jakob B, Ferrie, Jane E, Hooftman, W.E., Fransson, Eleonor I., Nyberg, Solja,, Westerholm, Peter, Fransson, Eleonor ,, Nyberg, Solja T.,, Zins, Marie,, Knutsson, A., Marmot, Michael G, Heikkilä, Katriina, Koskenvuo, Markku,, Heikkila, K., Heikkilä, Katriina,, Kivimaki, Mika,, Virtanen, Marianna,, Houtman, Irene ,, Borritz, M., Vahtera, J., Magnusson, Linda L., Bjorner, Jakob, B, V��n�nen, Ari, Madsen, Ida E. H.,, Batty, G David, Alfredsson, Lars, Bjorner, Jakob B., Ferrie, J.E., Ferrie, Jane ,, Nordin, M., Madsen, Ida Elisabeth Huitfeldt, Zins, Marie, Ferrie, Jane E., Alfredsson, L., Singh-Manoux, Archana, Vahtera, Jussi,, Nielsen, Martin L., Suominen, S., Goldberg, Marcel, Kivimäki, Mika, Singh-Manoux, Archana,, Madsen, I.E.H., Bjorner, J.B., Geuskens, Goedele ,, Kivimaki, M., Houtman, Irene L.,, Houtman, Irene L, Joensuu, Matti,, Oksanen, Tuula,, Bonenfant, Sebastien,, Geuskens, Goedele A., Hooftman, Wendela, E, Steptoe, Andrew,, Hooftman, Wendela ,, Hamer, M., Dragano, Nico,, Westerlund, H., Rugulies, R., Oksanen, T., Pentti, Jaana,, Burr, H., Rugulies, Reiner,, Marmot, Michael,, Theorell, Tores,, Suominen, Sakari, David, G., Alfredsson, Lars,, Koskinen, Aki, Koskenvuo, M., Bjorner, Jakob B.,, Nielsen, Martin, L, Geuskens, Goedele A, Steptoe, Andrew, Geuskens, G.A., Salo, P., Batty, G. David, Houtman, Irene,, Bjorner, Jakob ,, Zins, M., Marmot, Michael, Ferrie, Jane, Fransson, EI, Burr, Hermann, Nyberg, Solja, Madsen, Ida, Nielsen, Martin, Batty, David, Houtman, Irene, Magnusson Hanson, Linda, Geuskens, Goedele, Borritz, M, Bjorner, Jakob, Theorell, T,, Heikkila, K, Nyberg, ST, Bonenfant, S, Bouillon, K, Hooftman, Wendela, Alfredsson, L,, Bjorner, JB, Burr, H   +205 more
core   +1 more source

Influences of groundwater on air tightness and surrounding rock stability of CAES underground gas reservoir

Yantu gongcheng xuebao
The tightness and stability of compressed air energy storage (CAES) gas reservoir is the basis to ensure the safe operation of power station. There are many factors affecting the mechanics of gas reservoir and its mechanics characteristics are complex ...
WAN Fa 1, 3, JIANG Zhongming 1, 2, LIAO Junhui 1, LI Haifeng 3
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Predicting occupational strain and job satisfaction: The role of stress, coping, personality and affectivity variables [PDF]

, 1999
Four studies employed path analysis to examine how measures of occupational stressors, coping resources, and negative affectivity (NA) and positive affectivity (PA) interact to predict occupational strain.
Predicting Occupational Strain, Sutherland, Lynette F., Gerard J. Fogarty, Majella J. Albion, Gabrielle I. Lalor, Lalor, Gabrielle I., Susan Revitt, Albion, Majella J., Lynette F. Sutherl, Fogarty, Gerard J., M. Anthony Machin, Revitt, Susan, Machin, M. Anthony   +12 more
core   +1 more source

A stress free model for residual stress assessment using thermoelastic stress analysis [PDF]

, 2014
Thermoelastic Stress Analysis (TSA) has been proposed as a method of obtaining residual stresses. The results of a preliminary study demonstrated that when Al-2024 plate containing holes that were plastically deformed by cold expansion process to 2% and ...
Robinson, Andy, Howell, Geoff, Dulieu-Barton, Janice, Achintha, Mithila   +3 more
core   +1 more source

Finite Element Analysis of Stress-Strain between Human Head and Headrest of Office Chair

Journal of Mechanical Engineering
This study employs finite element analysis to evaluate the influence of office chair headrest curvature and inclination angle on head-headrest interaction.
Weikang Li, Hang Jiang, Chengfeng Wang, Zhengli Li, Ting Zhang, Onder Tor, İsmail Derda Güler, Lingling Hu   +7 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source