Results 71 to 80 of about 970,478 (306)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Performance of Concrete Confined with a Jute–Polyester Hybrid Fiber Reinforced Polymer Composite: A Novel Strengthening Technique

open access: yesFibers, 2019
The strengthening and rehabilitation of concrete members is an important issue which arises worldwide. Carbon, aramid and glass fiber reinforced polymer (FRP) composites are mainly used for strengthening and rehabilitation. However, its use is limited on
Nauman Wahab   +3 more
doaj   +1 more source

High temperature stress-strain analysis [PDF]

open access: yes
The objectives of the high-temperature structures program are threefold: to assist in the development of analytical tools needed to improve design analyses and procedures for the efficient and accurate prediction of the nonlinear structural response of ...
Moorhead, Paul E., Thompson, Robert L.
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Tensile stress-strain behavior of boron/aluminum laminates [PDF]

open access: yes
The tensile stress-strain behavior of five types of boron/aluminum laminates was investigated. Longitudinal and transverse stress-strain curves were obtained for monotonic loading to failure and for three cycles of loading to successively higher load ...
Poe, C. C., Jr., Sova, J. A.
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Analysis of silicon stress/strain relationships [PDF]

open access: yes
In the study of stress-strain relationships in silicon ribbon, numerous solutions were calculated for stresses, strain rates, and dislocation densities through the use of the Sumino model. It was concluded that many cases of failure of computer solutions
Dillon, O.
core   +2 more sources

Bearing transmits rotary and axial motion [PDF]

open access: yes, 1964
A low friction, two-component bearing comprised of a pair of ball-bearing races for transmitting rotary motion and an inner series of ball bearing assemblies for transmitting axial motion is described and should be useful in mechanisms such as stress ...
Dow, N. F., Peters, R. W.
core   +1 more source

Numerical simulation of the stress-strain state of the dental system

open access: yes, 2015
We present mathematical models, computational algorithms and software, which can be used for prediction of results of prosthetic treatment. More interest issue is biomechanics of the periodontal complex because any prosthesis is accompanied by a risk of ...
Lemeshevsky, Sergey V.   +4 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

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