Results 71 to 80 of about 483,350 (311)
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Black rubber and the non-linear elastic response of scale invariant solids
Journal of High Energy Physics, 2020 We discuss the nonlinear elastic response in scale invariant solids. Following previous work, we split the analysis into two basic options: according to whether scale invariance (SI) is a manifest or a spontaneously broken symmetry.
Matteo Baggioli +2 more
doaj +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
DISCRETE ELEMENT MODELING OF STRENGTH PROPERTIES AND FAILURE MODES OF QH-E LUNAR SOIL SIMULANT AT LOW CONFINING STRESSES [PDF]
Civil Engineering Journal, 2018 In this paper, discrete element method (DEM) is used to investigate the strength properties and failure modes of QH-E lunar soil simulant at the low confining stress.
Li Yun-Li +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
A damage-based constitutive model for rock under impacting load
International Journal of Mining Science and Technology, 2014 Using the Splitting Hopkinson Pressure Bar (SHPB) experimental system, investigations were made into the dynamic mechanical performances of underground soft rocks.
Guangming Zhao +2 more
doaj +1 more source
Mechanical Characterization of Anchor under Uniaxial Compression Loading Conditions
Advances in Materials Science and Engineering, 2022 Bolt reinforcement technology plays an important role in supporting the construction of many engineering fields, and the uniaxial loading characteristics and behavior tests of anchors have great significance to the research and application of anchors ...
Guanglin Sun +4 more
doaj +1 more source
Creep in fibre-reinforced polymer mat composites [PDF]
, 2007 Tensile creeps have been conducted upon a woven, glass-fibre laminated epoxy composite and a 0/90° cross ply, carbon fibre reinforced epoxy composite. For the laminate loading was aligned with a fibre direction.
Dix, S, Garner, AF, Rees, DWA
core
Stress-strain synchronization for high strain rate tests on brittle composites [PDF]
, 2018 Nowadays, many researchers develop rate-dependent composite material models for application in dynamic simulations. Ideally, full stress-strain curves at a wide range of strain rates are available for identification of the different parameters of these ...
Garoz Gómez, David +6 more
core +1 more source