Results 101 to 110 of about 371,044 (285)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
STRENGTH OF COMPOSITE YARN UNDER BIAXIAL LOADING
Acta Polytechnica CTU Proceedings, 2018 The present paper is concerned with two types of periodic unit cell of composite yarn with different geometry but the same material properties. Their macroscopic response under tensile and compressive loading in the transverse direction and their ...
Soňa Valentová +3 more
doaj +1 more source
Band-filling effects on electron-phonon properties of normal and superconducting state
, 2003 We address the effect of band filling on the effective electron mass $m^*$ and the superconducting critical temperature $T_c$ in a electron-phonon system.
A. Georges +39 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Utilisation of the method of stress limit for designing the motion screw dimensions
Research in Agricultural Engineering, 2008 A design of the motion screw using the method of stress limit is described. Further general formulas are induced to design such kind of screws, applied to an example of 11500 (EN ISO E295) steel made screw, strained by static operational force.
D. Herák +2 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
, 2015 The Virasoro algebra determines all `graviton' matrix elements in AdS$_3$/CFT$_2$. We study the explicit exchange of any number of Virasoro gravitons between heavy and light CFT$_2$ operators at large central charge.
Fitzpatrick, A. Liam +3 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Three-graviton scattering in Matrix theory revisited
, 1998 We consider a subset of the terms in the effective potential describing three-graviton interactions in Matrix theory and in classical eleven-dimensional supergravity. In agreement with the results of Dine and Rajaraman, we find that these terms vanish in
Banks +7 more
core +1 more source