Results 121 to 130 of about 371,044 (285)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Research of Fatigue Life of Spinning Pulley Under Different Cycle Characteristics

Jixie chuandong, 2017
Taking spinning pulley with a slit in the automobile booster pump as study object,the stress limit diagram with different cycle characteristics are discussed.
Weng Jiancheng
doaj  

Phase diagrams of the 2D t-t'-U Hubbard model from an extended mean field method

, 2004
It is well-known from unrestricted Hartree-Fock computations that the 2D Hubbard model does not have homogeneous mean field states in significant regions of parameter space away from half filling. This is incompatible with standard mean field theory.
A. Singh, B. Valenzuela, C. Honerkamp, D. Penn, D. Poilblanc, E. Dagotto, E. Demler, E. H. Lieb, E. Langmann, E. Langmann, Edwin Langmann, F. C. Zhang, H. Q. Lin, H. Taniguchi, H. X. Huang, J. A. Verges, J. C. Slater, J. E. Hirsch, J. Zaanen, L. Arrachea, M. Imada, M. S. Hybertsen, Mats Wallin, P. A. Lee, P. B. Visscher, P. W. Anderson, Q. H. Wang, V. Bach, V. Bach, V. Bach, W. P. Su, Y. Nagaoka   +31 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Optimal Design of Specimens for Pure Shear Tests of Sheet Metals

Engineering Transactions, 1994
A new type of simple specimens for experimental testing of plastic properties of sheet metals under pure shear conditions is proposed and optimized.
G. Socha
doaj  

Threshold Pion Electroproduction in Chiral Perturbation Theory

, 1993
Electroproduction of pions on the nucleon near the threshold is analyzed within the framework of baryon chiral perturbation theory. We give a thorough discussion of the low--energy theorems related to charged and neutral electropionproduction.
Adler, Adler, Ahrens, Ahrens, Amaldi, Amendolia, Beck, Berends, Bernard, Bernard, Bernard, Bernard, Bernard, Bernard, Bernard, Bernard, Bernard, Choi, Coleman, de Baenst, del Guerra, Dombey, Donoghue, Ecker, Fubini, Gasser, Gasser, Gasser, Gasser, Gasser, Gasser, Gasser, Jenkins, Kitagaki, Krause, Kroll, Meißner, Meißner, N. Kaiser, Nambu, Nambu, Nozawa, Nozawa, Ohta, Olsson, Park, Riazuddin, Scherer, Scherer, T.-S.H. Lee, Ulf-G. Meißner, V. Bernard, Vainshtein, Weinberg, Weinberg, Welch   +55 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source