Results 91 to 100 of about 2,700,982 (237)

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression

Scientific Reports
Understanding how mechanical stress affects erythropoiesis is crucial to produce transfusable erythrocytes in fluid-turbulent bioreactors. We investigated the effects of shear-stress on differentiating CD49d+CD235a+ primary human erythroblasts (EBL) at ...
Giulia Iacono, Asena Abay, Joan S. Gallego Murillo, Francesca Aglialoro, Nurcan Yagci, Eszter Varga, Tieme Bijlsma, Justine Sohler, Kerly Fu, Julie A. Reisz, Amy Argabright, Angelo D’Alessandro, Arthur F. Svendsen, Marieke von Lindern, Emile van den Akker   +14 more
doaj   +1 more source

Late stage erythroid precursor production is impaired in mice with chronic inflammation

Haematologica, 2012
Background We and others have shown previously that over-expression of hepcidin antimicrobial peptide, independently of inflammation, induces several features of anemia of inflammation and chronic disease, including hypoferremia, sequestration of iron ...
Olivier D. Prince, Jacqueline M. Langdon, Andrew J. Layman, Ian C. Prince, Miguel Sabogal, Howard H. Mak, Alan E. Berger, Chris Cheadle, Francis J. Chrest, Qilu Yu, Nancy C. Andrews, Qian-Li Xue, Curt I. Civin, Jeremy D. Walston, Cindy N. Roy   +14 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Hematological and Genotoxic Effects of Subchronic Oral Exposure to a Mancozeb‐Based Fungicide in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The extensive use of pesticides in modern agriculture has raised increasing concerns regarding the potential biological effects of repeated exposure to pesticide residues and commercial formulations. Mancozeb is a widely used ethylene‐bis‐dithiocarbamate fungicide; however, information on its hematological and genotoxic effects following ...
Matheus Henrique Barcelos Figueiredo, Natanael Vaz Crisóstomo Peixoto, Paula Soares Nakamura, Cecília Müller Wodzik, Lucas Ribeiro Maia dos Santos, Fábio Vieira de Andrade Borges, Lara Cândida de Sousa Machado, Jéssica Gardone Vitório, Renata Mazaro e Costa, Mônica Rodrigues Ferreira Machado, Walter Dias Júnior   +10 more
wiley   +1 more source

Metabolic reprogramming during ineffective erythropoiesis in β-thalassemia/HbE disease

Experimental and Molecular Pathology
Ineffective erythropoiesis, the main cause of anemia in β-thalassemia disease, is characterized by dramatic expansion of erythroblasts and increased erythroblast cell death.
Chanyanat Sukhuma, Donny Nauphar, Khanita Nuamsee, Wasinee Kheansaard, Kittiphong Paiboonsukwong, Alisa Wilantho, Chumpol Ngamphiw, Pornthip Chaichompoo, Sissades Tongsima, Saovaros Svasti, Phatchariya Phannasil   +10 more
doaj   +1 more source

MRI Proton Density Fat Fraction as a Biomarker of Marrow Recovery Following Organ‐Sparing Total Marrow Irradiation in Sickle Cell Disease

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Noninvasive quantitative assessment of marrow recovery after curative therapies such as total marrow irradiation (TMI) and bone marrow transplantation (BMT) remain poorly defined, particularly in sickle cell disease (SCD). Purpose To evaluate MRI‐derived proton density fat fraction (PDFF) as a biomarker of marrow recovery following ...
Malakeh Malekzadeh, Hemendra Ghimire, Ji Eun Lim, Srideshikan S. Madabushi, Weidong Hu, Marco Andrea Zampini, Kazuki Fujita, Raghda Fouda, Guy Storme, Joo Song, Bihong T. Chen, Anna Pawlowska, Susanta K. Hui   +12 more
wiley   +1 more source

Comparative Proteome-Wide Analysis of Bone Marrow Microenvironment of β-Thalassemia/Hemoglobin E

Proteomes, 2019
β-thalassemia/Hb E is a global health issue, which is characterized by a range of clinical symptoms from a mild and asymptomatic anemia to severe disorders that require transfusions from infancy.
Saranyoo Ponnikorn, Rungrawee Mongkolrob, Suwit Klongthalay, Sittiruk Roytrakul, Kitima Srisanga, Sumalee Tungpradabkul, Suradej Hongeng   +6 more
doaj   +1 more source

Anaemia in patients diagnosed with paediatric‐onset inflammatory bowel disease: A Danish nationwide cohort study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Anaemia impairs daily activities and quality of life in patients with paediatric‐onset inflammatory bowel disease (PIBD). This study aimed to investigate the prevalence of anaemia at PIBD‐diagnosis and the following 5 years. Furthermore, anaemia subtypes and the association between anaemia and disease activity were assessed over ...
Julie Rahbek Norup, Sabine Jansson, Vibeke Wewer, Mikkel Malham   +3 more
wiley   +1 more source

The effects of royal jelly on human health: A narrative review of clinical studies

JSFA reports, EarlyView.
Abstract Royal jelly (RJ) is a natural bioactive substance with documented effects on human health. This narrative review synthesizes evidence from clinical and clinically relevant experimental studies evaluating the therapeutic potential of RJ.
Georgios Goras, Andreas Thrasyvoulou, Evanthia Tsilimpokou   +2 more
wiley   +1 more source