Results 181 to 190 of about 2,700,982 (237)

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, Volume 255, Issue 9, Page 896-914, September 2026.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, Volume 58, Issue 5, Page 1413-1444, September 2026.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Inherited microcytic anemias due to disorders of iron and heme metabolism: An updated clinical review

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Microcytic anemia is among the most common hematological abnormalities in clinical practice and is usually attributable to iron deficiency, thalassemia traits, or anemia of inflammation. A small but clinically important subset of patients, however, has inherited disorders of iron metabolism or heme synthesis presenting with persistent ...
Alexandros Makis, Ioanna Saougou, Eleftheria Hatzimichael   +2 more
wiley   +1 more source

Dissecting Bone Marrow Fibrosis in Philadelphia‐Negative Myeloproliferative Neoplasms: Multiple Roads Lead to Rome

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Philadelphia‐negative myeloproliferative neoplasms (MPN), a spectrum of blood malignancies characterized by uncontrolled myeloid proliferation, persist as a key challenge in onco‐hematology due to their intricate molecular background, heterogeneous clinical phenotypes, and variable prognoses.
Mariagiovanna Ballato, Vincenzo Fiorentino, Gabriele Ricciardi, Pietro Tralongo, Emanuela Germanà, Alessandro Allegra, Fabio Stagno, Guido Fadda, Maurizio Martini   +8 more
wiley   +1 more source

Bone marrow characterization in sickle cell disease: inflammation and stress erythropoiesis lead to suboptimal CD34 recovery. [PDF]

Br J Haematol, 2019
Leonard A, Bonifacino A, Dominical VM, Luo M, Haro-Mora JJ, Demirci S, Uchida N, Pierciey FJ, Tisdale JF.   +8 more
europepmc   +1 more source

Prognostic Significance of Peripheral Blood Neutrophil‐To‐Lymphocyte Ratio (NLR), Monocyte‐To‐Lymphocyte Ratio (MLR), and Platelet‐To‐Lymphocyte Ratio (PLR) in Patients With Multiple Myeloma: A Retrospective Cohort Study

Journal of Clinical Laboratory Analysis, Volume 40, Issue 17, September 2026.
This graphical abstract illustrates the prognostic significance of systemic inflammatory markers in Multiple Myeloma (MM). The left panel depicts the immunosuppressive tumor microenvironment, where abundant neutrophils and M2 macrophages promote MM cell survival while lymphocytes are depleted.
Lihong Zhang, Bing Ma, Jingyu Zhang
wiley   +1 more source

Impact of Anemia and Comorbidity Burden on Disease Progression and Outcomes in Chronic Kidney Disease

Journal of Clinical Laboratory Analysis, Volume 40, Issue 17, September 2026.
This study evaluates the prognostic value of immuno‐hematological markers—including anemia status, RDW, hemoglobin levels, and multimorbidity burden—in predicting chronic kidney disease (CKD) progression among adult patients. Findings reveal that anemia and the presence of ≥ 2 comorbidities strongly amplify the risk of CKD progression and ...
Collince Odiwuor Ogolla, Stanslaus Musyoki, Lucy W. Karani, Phidelis Maruti   +3 more
wiley   +1 more source

Mitochondrial CLPP in Health and Disease: Mechanisms, Therapeutic Duality and Emerging Opportunities

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
The graphical abstract illustrates the context‐dependent therapeutic modulation of CLPP. Pharmacological CLPP activation has reached clinical application in cancer (black arrow), whereas reduced CLPP activity has shown beneficial effects experimentally in models of primary mitochondrial disease and metabolic syndrome, as well as cancer (grey arrows ...
Lea Isermann, Aleksandra Trifunovic
wiley   +1 more source

My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT The intervertebral disc is a prime example of tissue adaptation to metabolic and mechanical extremes. As the largest avascular organ in the human body, the disc and the central nucleus pulposus (NP) endure constant compressive loading while sustaining a hypoxic, relatively acidic, and hyperosmotic microenvironment that would be inhospitable to
Makarand V. Risbud
wiley   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source