Results 111 to 120 of about 1,074,800 (318)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Clinical Evaluation of Stress: An Opinion [PDF]

Preventive Cardiology, 2000
C T, Kappagoda, D, Court, S, Myers, E, Perry   +3 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Nondestructive Evaluation of Green Dimension Lumber Using Stress Wave and Transverse Vibration Techniques

, 1996
Predicting the material properties of wood through nondestructive evaluation (NDE) techniques is a matter of considerable importance for the timber industry.
Robert J. Ross, Udaya B. Halabe, Hota V. S. GangaRao, Bidigalu, Gangadhar, Gangadhar M. Bidigalu, GangaRao, Hota, Ross, Robert, Halabe, Udaya   +7 more
core   +1 more source

Extreme Kinetic Stability and RNase Resistance of Human Telomerase RNA G‐Quadruplexes Overcome by DHX36 Helicase

Advanced Science
RNA G‐quadruplexes (G4s) formed at the 5′‐end of the RNA component of human telomerase (hTR) are known to directly affect telomerase activity. However, the unfolding kinetics of hTR1–18 G4s at physiological K+ conditions have not been analyzed due to ...
Qun Luo, Yashuo Zhang, Yingxian Qian, Huiying Zhan, Wenqiang Wu, Huijuan You   +5 more
doaj   +1 more source

A Case Series of Psychological Stress Evaluation as a Risk Factor for Oral Lichen Planus. [PDF]

Case Rep Dent, 2022
Sufiawati I, Megawati A, Al Farisyi M, Putra INGJ.   +3 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Prevalence of posttraumatic stress symptoms in health care workers after exposure to patients with COVID-19

, 2020
Objective: To investigate the prevalence of posttraumatic stress symptoms (PTSS) of health care workers (HCWs) who were potentially or directly exposed to patients with coronavirus disease 2019 (COVID-19) in a non-core epidemic area of China. Methods:
Wan, Bo, Cheng, Yanbo, Zhao, Zhong, Xu, Xingshun, Muhammad, Bilal, Li, Shengli, Abdul, Mannan, Geng, Deqin, Chen, Hao, Wang, Bin, Miao, Zhigang   +10 more
core   +1 more source

Stress Evaluation by Hemoglobin Concentration Change Using Mobile NIRS. [PDF]

Brain Sci, 2022
Takahashi S, Sakurai N, Kasai S, Kodama N.   +3 more
europepmc   +1 more source