Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 2014 The buffering effect of core self-evaluation (CSE) in stress research has received academic attention. However, most research in this area focused on its moderating effect on well-being.
Lin, Jingyu, Yuan, Zhenyu, Li, Yongjuan
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, 2006 Design and life assessment procedures for high temperatures are based on 'expert knowledge' in structural mechanics and materials science, combined with simplified methods of structural analysis. Of these R5 is one of the most widely used life assessment
Chen, Haofeng +2 more
core +1 more source
In Vitro Cytotoxicity and Oxidative Stress Evaluation of Valerian (Valeriana officinalis) Methanolic Extract in Hepg2 and Caco2 Cells [PDF]
Turk J Pharm Sci, 2021 Kara M +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Elevated Temperature Baseplate Effect on Microstructure, Mechanical Properties, and Thermal Stress Evaluation by Numerical Simulation for Austenite Stainless Steel 316L Fabricated by Directed Energy Deposition. [PDF]
Materials (Basel), 2022 Kiran A +8 more
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Residual stress evolution analysis in AZ31 friction stir welds using X-Ray and neutron diffraction [PDF]
, 2009 This work was performed as a part of AEROMAG Project"Aeronautica lApplication of Wrought Magnesium" (project N°AST4-CT-2005 -516152) which was supported by the European Union.The authors wish to thank EADS-I W F, Suresnes for Friction Stir Welding,Robert
COMMIN, Loreleï +2 more
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Research progress on stress reaction evaluation
Huli yanjiu, 2005 It introduced the occurrence, biochemical and psychological indexes evaluation of stress reaction in recent years. It put forward that to probe the rule of stress reaction further and to improve the evaluation indexes of stress reaction continually have ...
翟惠敏, 李亚洁
doaj