Results 101 to 110 of about 9,498,112 (294)

Spatiotemporal transcriptome and metabolome landscapes of cotton fiber during initiation and early development

Nature Communications
Cotton fibers are single cells that develop from the epidermal cells in the outer integument of developing seeds. The processes regulating fiber cell development have been extensively studied; however, the spatiotemporal transcriptome and metabolome ...
Xuwu Sun, Aizhi Qin, Xingxing Wang, Xiaoyang Ge, Zhixin Liu, Chenxi Guo, Xiaole Yu, Xianliang Zhang, Yao Lu, Jincheng Yang, Jiuming He, Yaping Zhou, Yumeng Liu, Mengke Hu, Hao Liu, Zihao Zhao, Guanjing Hu, Wei Li, Xinshan Zang, Shuai Dai, Susu Sun, Lenin Yong-Villalobos, Luis Herrera-Estrella, Lam-Son Phan Tran, Xiongfeng Ma   +24 more
doaj   +1 more source

The effects of psychosocial stress on dopaminergic function and the acute stress response

eLife, 2019
Chronic psychosocial adversity induces vulnerability to mental illnesses. Animal studies demonstrate that this may be mediated by dopaminergic dysfunction. We therefore investigated whether long-term exposure to psychosocial adversity was associated with
Michael AP Bloomfield, Robert A McCutcheon, Matthew Kempton, Tom P Freeman, Oliver Howes   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

MARCH5 inactivation supports mitochondrial function during neurodegenerative stress

Frontiers in Cellular Neuroscience, 2013
Neuronal cell death is accompanied by mitochondrial dysfunction with mitochondrial maintenance critical to neuronal survival. The mitochondrial ubiquitin ligase MARCH5 has dual roles in the upkeep of mitochondrial function. MARCH5 is involved in targeted
Lei eFang, Jia eLi, Jia eLi, Josef eFlammer, Albert eNeutzner, Albert eNeutzner   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Maternal stress and adolescent brain structure and function

Brain and Behavior, 2019
Introduction Adolescence is a time of heightened sensitivity in biological stress systems and the emergence of stress‐related psychopathology. Thus, understanding environmental factors in adolescence that might be associated with adolescents'’ stress ...
Claire E. Niehaus, Tara M. Chaplin, Stefanie F. Gonçalves, Robin Semelsberger, James C. Thompson   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Executive function and attention in patients with stress-related exhaustion: perceived fatigue and effect of distraction

, 2017
Cognitive impairment has frequently been shown in patients who seek medical care for stress-related mental health problems. This study aims to extend the current knowledge of cognitive impairments in these patients by focusing on perceived fatigue and ...
Jonsdottir, I. H., Samuelsson, Hans,, Ingibjörg H. Jonsdottir, Nilsson, Michael,, Hans Samuelsson, David Krabbe, Krabbe, David,, Michael Nilsson, Ellbin, S., Susanne Ellbin   +9 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source