Results 241 to 250 of about 128,066 (353)

TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor [PDF]

, 2010
Colleen M. Dewey, Basar Cenik, Chantelle F. Sephton, Daniel R. Dries, Paul R. Mayer, Shannon K. Good, Brett A. Johnson, Joachim Herz, Gang Yu   +8 more
openalex   +1 more source

Accelerated Cellular Senescence in Progressive Multiple Sclerosis: A Histopathological Study

Annals of Neurology, EarlyView.
Objective The neurodegenerative processes driving the build‐up of disability in progressive multiple sclerosis (P‐MS) have not been fully elucidated. Recent data link cellular senescence (CS) to neurodegeneration. We investigated for evidence of CS in P‐MS and sought to determine its pattern.
Dimitrios Papadopoulos, Roberta Magliozzi, Sara Bandiera, Ilaria Cimignolo, Elena Barusolo, Lesley Probert, Vassilis Gorgoulis, Richard Reynolds, Richard Nicholas   +8 more
wiley   +1 more source

Lactic acid bacteria isolated from traditional Iranian butter with probiotic and cholesterol‐lowering properties: In vitro and in situ activity

Food Science &Nutrition, Volume 11, Issue 1, Page 350-363, January 2023., 2023
Traditional Iranian butter samples were collected from different parts of Iran and were screened for the presence of Lactic acid bacteria. The selected LAB were identified to species level by biphasic approach. The ability of selected LAB to lower the cholestrol both in vitro and in situ was then determined.
Mahbubeh Ostadzadeh, Mohammad B. Habibi Najafi, Mohammad R. Ehsani   +2 more
wiley   +1 more source

Association Between Vascular NOTCH3 Aggregation and Disease Severity in a CADASIL Cohort – Implications for NOTCH3 Variant‐Specific Disease Prediction

Annals of Neurology, EarlyView.
Objective Vascular NOTCH3 protein ectodomain aggregation is a pathological hallmark of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a monogenic small vessel disease typically caused by cysteine‐altering variants in NOTCH3.
Minne N. Cerfontaine, Gido Gravesteijn, Remco J. Hack, Kyra L. Dijkstra, Mar Rodríguez‐Girondo, Benno Gesierich, Marie‐Noëlle W. Witjes‐Ané, Remco van Doorn, Marco Duering, Julie W. Rutten, Saskia A. J. Lesnik Oberstein   +10 more
wiley   +1 more source

The role of posttranslational modifications in the assembly of stress granules [PDF]

, 2010
Takbum Ohn, Paul Anderson
openalex   +1 more source

Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy

Glia, Volume 71, Issue 2, Page 168-186, February 2023., 2023
Main Points Microglia become rapidly reactive in temporal lobe epilepsy (TLE). Microglia are major producers of TNFα during status epilepticus, which impairs astrocyte coupling and promotes gliosis. Depletion of microglia attenuates acute seizure activity in TLE.
Lukas Henning, Henrike Antony, Annika Breuer, Julia Müller, Gerald Seifert, Etienne Audinat, Parmveer Singh, Frederic Brosseron, Michael T. Heneka, Christian Steinhäuser, Peter Bedner   +10 more
wiley   +1 more source

Is microglial dystrophy a form of cellular senescence? An analysis of senescence markers in the aged human brain

Glia, Volume 71, Issue 2, Page 377-390, February 2023., 2023
Main Points Aging‐related morphological changes in microglia (dystrophy) do not correlate with expression of universal senescence markers. Microglial dystrophy coincides with an aging‐related increase in microglial ferritin expression. Abstract Aging can cause morphological transformation in human microglia indicative of cell senescence, termed ...
Pauline Neumann, Dana E. Lenz, Wolfgang J. Streit, Ingo Bechmann   +3 more
wiley   +1 more source

Data‐Driven Review on Aerogels and Polymeric Aerogels

Angewandte Chemie International Edition, Accepted Article.
Thoroughly data‐driven review on chemistry–properties–applications of aerogels is provided. Aerogel is a category of solid materials having homogeneous, highly porous nanostructures. Unique physicochemical properties of aerogels have attracted much attention in wide fields due to their potentials for energy/environmental issues in the 21st century ...
Satoru Takeshita, Shinya Mine, Takumi Ono   +2 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Rotavirus Infection Induces the Phosphorylation of eIF2α but Prevents the Formation of Stress Granules

, 2007
Hilda Montero, Margarito Rojas, Carlos F. Arias, Susana López   +3 more
openalex   +1 more source