Results 131 to 140 of about 77,443 (288)
eLifeRibonucleoprotein (RNP) granules are membraneless electron-dense structures rich in RNAs and proteins, and involved in various cellular processes. Two RNP granules in male germ cells, intermitochondrial cement and the chromatoid body (CB), are associated
Yuki Kaneda +7 more
doaj +1 more source
Advanced Science, EarlyView.STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang +8 more
wiley +1 more source
Stress granules (SG) and processing bodies (PB) in viral infections
, 2016 During reaction to stress caused by viral infection, RNA granules are formed in order to protect mRNA. Stress granules (SG) and processing bodies (PB) provide cell homeostasis and mRNA stability.
Tokarz-Deptuła, Beata +3 more
core +1 more source
Advanced Science, EarlyView.Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral +7 more
wiley +1 more source
NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination
Nature CommunicationsThe NS1 binding protein, known for interacting with the influenza A virus protein, is involved in RNA processing, cancer, and nerve cell growth regulation. However, its role in stress response independent of viral infections remains unclear.
Pureum Jeon +12 more
doaj +1 more source
Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound
Advanced Science, EarlyView.Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García +11 more
wiley +1 more source
Lsm12 and Pbp4 localize to stress granules.
, 2013 GFP-tagged Lsm12 and Pbp4 were assessed for their ability to form granules that co-localize with either Edc3-mCherry, a P-body marker, or with Pub1-mCherry, a stress granule marker, following ten minutes of glucose deprivation stress.
Roy Parker (315449) +1 more
core +1 more source
Advanced Science, EarlyView.A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu +5 more
wiley +1 more source
Molecular and Cellular ProbesHuntington's disease (HD) arises from the abnormal expansion of a CAG repeat in the HTT gene. The mutant CAG repeat triggers aberrant RNA-protein interactions and translates into toxic aggregate-prone polyglutamine protein.
Deepti Kailash Nabariya +5 more
doaj +1 more source
Xrn1 associates with heat-induced stress granules.
, 2015 Localization patterns of Xrn1-GFP and eIF3a-RFP in exponentially growing cells (strain CRY2104) at 30°C (A) and upon heat stress at 46°C (B) were correlated.
Tomas Grousl (382128) +4 more
core +1 more source