Results 191 to 200 of about 3,973,918 (385)

Mas Signaling Potentiates Neutrophil Extracellular Traps Formation Induced by Endothelial Cells Derived S1P in Mice with Acute Liver Failure

Advanced Science, EarlyView.
In mice challenged with lipopolysaccharide/D‐galactosamine (L/G), Mas signaling increased SHP2 in hepatic Col4a1+ endothelial cells, inhibiting farnesoid X receptor (FXR), potentially due to enterogenic deoxycholic acid. This inhibition activates sphingosine‐1‐phosphate‐induced Raf/MEK/ERK signaling in Cldn1+CD177+ neutrophils, causing neutrophil ...
Bo Yang, Shuai Chen, Xiaoqi Xia, Ziwen Tao, Chun Liu, Shanshan Li, Shuo Zhang, Jiali Huang, Lu Xia, Wenqiang Quan, Changqing Yang, Jing Li   +11 more
wiley   +1 more source

A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy

Nature Communications, 2018
Many Amyotrophic Lateral Sclerosis (ALS)-linked mutations cause accumulation of stress granules, and most ALS cases are caused by repeat expansions in C9ORF72.
Maneka Chitiprolu, Chantal Jagow, Veronique Tremblay, Emma Bondy-Chorney, Geneviève Paris, Alexandre Savard, Gareth Palidwor, Francesca A. Barry, Lorne Zinman, Julia Keith, Ekaterina Rogaeva, Janice Robertson, Mathieu Lavallée-Adam, John Woulfe, Jean-François Couture, Jocelyn Côté, Derrick Gibbings   +16 more
doaj   +1 more source

Granules Harboring Translationally Active mRNAs Provide a Platform for P-Body Formation following Stress

Cell Reports, 2014
The localization of mRNA to defined cytoplasmic sites in eukaryotic cells not only allows localized protein production but also determines the fate of mRNAs.
Jennifer Lui, Lydia M. Castelli, Mariavittoria Pizzinga, Clare E. Simpson, Nathaniel P. Hoyle, Kathryn L. Bailey, Susan G. Campbell, Mark P. Ashe   +7 more
doaj   +1 more source

Particle Size Control by Torque Measurements in Fluidized Beds during Drying and Granulation from Solutions [PDF]

, 2001
The fluidized bed process presented in this paper is suitable to recover solids from solution in form of granules. Solution is sprayed into the bed and, as the solvent evaporates, solid material is deposited on the surface of fluidizing particles ...
Dencs, B., Gyenis, János, Tardos, I. G.
core  

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source

Regulated protein aggregation: stress granules and neurodegeneration

Molecular Neurodegeneration, 2012
The protein aggregation that occurs in neurodegenerative diseases is classically thought to occur as an undesirable, nonfunctional byproduct of protein misfolding. This model contrasts with the biology of RNA binding proteins, many of which are linked to
Wolozin Benjamin
doaj   +1 more source

MEA‐seqX: High‐Resolution Profiling of Large‐Scale Electrophysiological and Transcriptional Network Dynamics

Advanced Science, EarlyView.
How can we fully understand brain function and disease without uncovering the causal coordination between molecular and neural activity across space and time? MEA‐seqX tackles this challenge by integrating advanced electrophysiology, spatial transcriptomics, and artificial intelligence predictions, revealing multiscale dynamics.
Brett Addison Emery, Xin Hu, Diana Klütsch, Shahrukh Khanzada, Ludvig Larsson, Ionut Dumitru, Jonas Frisén, Joakim Lundeberg, Gerd Kempermann, Hayder Amin   +9 more
wiley   +1 more source

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

Cell, 2020
Peiguo Yang, Cécile Mathieu, Regina-Maria Kolaitis, Peipei Zhang, James Messing, Ugur Yurtsever, Zemin Yang, Jinjun Wu, Yuxin Li, Qingfei Pan, Jiyang Yu, Erik W. Martin, Tanja Mittag, Hong Joo Kim, J. P. Taylor   +14 more
semanticscholar   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Macroscopic material properties from quasi-static, microscopic simulations of a two-dimensional shear-cell [PDF]

Granular Matter vol.2 iss.3 2000, 2000
One of the essential questions in the area of granular matter is, how to obtain macroscopic tensorial quantities like stress and strain from ``microscopic'' quantities like the contact forces in a granular assembly. Different averaging strategies are introduced, tested, and used to obtain volume fractions, coordination numbers, and fabric properties ...
arxiv