This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao+7 more
wiley +1 more source
Controlled Film Flow in Granulation of Metals for the Development of Amorphous Superhard and Functionally Unique New Materials [PDF]
The problem of granulation is very bright by the granulated materials, as well as by their application. In the paper, some history of the granulation problem during over century and modern applications of the metallic granulates and amorphous materials are given at the beginning. Then the specific own granulation problem is presented, which has concern
arxiv
Alteration of cytosolic free calcium homeostasis by SIN‐1: high sensitivity of L‐type Ca2+ channels to extracellular oxidative/nitrosative stress in cerebellar granule cells [PDF]
Yolanda Gutiérrez‐Martín+3 more
openalex +1 more source
Small cell lung cancer (SCLC) harbors high molecular heterogeneity. Using a new liquid biopsy assay, SCLC subtypes can be identified by measuring mRNA of subtype transcription factors (ASCL1, POU2F3, and NEUROD1) in exosome‐rich extracellular vesicles. Combining with Delta‐like ligand 3 (DLL3) mRNA in exosomes and its membrane protein in extracellular ...
Hong Li+27 more
wiley +1 more source
Self‐Assembly of Linear, Natural Antimicrobial Peptides: An Evolutionary Perspective
Antimicrobial peptides are an ancient defence against a wide range of microbes. Some can self‐assemble into oligomers and amyloid. Similarities with neurodegenerative diseases support a hypothesis that some diseases are due to aberrant activity of a protective neuropeptide.
Verity Baltutis+2 more
wiley +1 more source
Lifting a granular box by a half-buried rod [PDF]
We studied an interesting experiment that showed a half-buried chopstick lifting a full bottle of granules off the table. In Janssen theory, the friction force provided by the container wall helps alleviate the weight of the granules. How can a thin rod with a much less contact area support the full weight plus that of the container?
arxiv
Heme-regulated Inhibitor Kinase-mediated Phosphorylation of Eukaryotic Translation Initiation Factor 2 Inhibits Translation, Induces Stress Granule Formation, and Mediates Survival upon Arsenite Exposure [PDF]
Edward L. McEwen+8 more
openalex +1 more source
Tomato chlorosis virus (ToCV) infection induces production of neophytadiene, a volatile resulting from chlorophyll degradation that is highly attractive to whiteflies. OBP2, an odorant‐binding protein from insect vector B. tabaci, exhibits a strong binding affinity for neophytadiene.
Xiao‐bin Shi+14 more
wiley +1 more source
NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination
The NS1 binding protein, known for interacting with the influenza A virus protein, is involved in RNA processing, cancer, and nerve cell growth regulation. However, its role in stress response independent of viral infections remains unclear.
Pureum Jeon+12 more
doaj +1 more source
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao+15 more
wiley +1 more source