Results 91 to 100 of about 2,487,134 (354)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Direct Computation of 3-D Stress Intensity Factors of Straight and Curved Planar Cracks with the P-Version Finite Element Method and Contour Integral Method. [PDF]

Materials (Basel), 2021
Zhang J, Xu R, He Y, Yang W.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Mixed mode stress intensity factors for semielliptical surface cracks [PDF]

The three-dimensional equations of elasticity are solved for a flat elliptical crack which has nonuniform shear stresses applied to its surfaces. An alternating method is used to determine the mode two and mode three stress intensity factors for a ...
Smith, F. W., Sorensen, D. R.
core   +1 more source

Stress intensity factors of interfacial cracks

Engineering Fracture Mechanics, 1993
Abstract A comparison of mode I and II stress intensity factors at the interfacial crack tip arising from different applied loads and edge dislocation is made. Under the action of point load the stress intensity factor oscillates with the distance from the position of applied load to the crack tip, but there is no oscillation in the stress intensity ...
Zhang, Tongyi, Lee, Sanboh
openaire   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A New Displacement-based Approach to Calculate Stress Intensity Factors With the Boundary Element Method

Latin American Journal of Solids and Structures
The analysis of cracked brittle mechanical components considering linear elastic fracture mechanics is usually reduced to the evaluation of stress intensity factors (SIFs).
Marco Gonzalez, Paulo Teixeira, Luiz C. Wrobel, Manuel Martinez   +3 more
doaj   +1 more source

A cracked orthotropic sheet stiffened by a semi-infinite orthotropic sheet [PDF]

The stress intensity factor is determined for a cracked orthotropic sheet adhesively bonded to an orthotropic stringer. Since the stringer is modeled as a semiinfinite sheet, the solution is most appropriate for a crack tip located near a stringer edge ...
Bigelow, C. A.
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Calibration of NASGRO equation for mixed-mode loading using experimental and numerical data

Revista Facultad de Ingeniería Universidad de Antioquia, 2019
A procedure to calibrate the NASGRO equation in a high yield-strength steel under mixed-mode loading (I+II) is presented. The calibration consists in obtaining the material parameters known as C, m, p and q.
David Reynaldo Berrios-Barcena, Rosendo Franco-Rodríguez, Francisco Aurelio Rumiche-Zapata   +2 more
doaj   +1 more source