Results 71 to 80 of about 2,487,134 (354)

Three dimensional finite-element analysis of finite-thickness fracture specimens [PDF]

The stress-intensity factors for most of the commonly used fracture specimens (center-crack tension, single and double edge-crack tension, and compact), those that have a through-the-thickness crack, were calculated using a three dimensional finite ...
Newman, J. C., Jr., Raju, I. S.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Shear-stress intensity factors for elastic sheets with cover plates [PDF]

Shear stress intensity factors are calculated for three problems concerning inextensible cover plates either bonded to or embedded in an elastic sheet which is under uniaxial tension.
Fichter, W. B.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Stress-intensity factors for internal surface cracks in cylindrical pressure vessels [PDF]

The stress intensity factors were calculated by a three dimensional finite element method. The finite element models employed singularity elements along the crack front and linear strain elements elsewhere.
Newman, J. C., Jr., Raju, I. S.
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Сoncentrated force acting near the tip of an interface crack with a rigid overlay on its side

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011
Plane stress state near the tip of an interface crack induced by specified concentrated force is considered. One of the crack faces is partially reinforced by a rigid straight line overlay.
Yulia O Vasilyeva, Vasiliy V Silvestrov
doaj  

Effect of crack position and size of particle on SIF in SiC particles reinforced Al composite

Fracture and Structural Integrity, 2019
In this paper the effect of reinforcement crack position and loading conditions (in mode I) on the stress intensity factors of the Al/SiCp metal matrix composite was examined using a finite element method.
Aicha Metehri, Madani Kouider, Abdelkader Lousdad   +2 more
doaj   +1 more source

Fracture analysis-based mode-I stress intensity factors of crack under fracture grouting in elastic-plastic soils. [PDF]

Sci Rep, 2023
Li L, Deng Y.
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source