Results 41 to 50 of about 51,374 (258)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Determining the stress field in active volcanoes using focal mechanisms

Frontiers in Earth Science, 2016
Stress inversion of seismological datasets became an essential tool to retrieve the stress field of active tectonics and volcanic areas. In particular, in volcanic areas, it is able to put constrains on volcano-tectonics and in general in a better ...
Bruno Massa, Bruno Massa, Luca D'Auria, Luca D'Auria, Elena Cristiano, Ada De Matteo   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Theoretical and Experimental Study on Parameter Optimization of Active Sources in Seismic Tomography [PDF]

Lithosphere
Given the high cost of active seismic tomography and the large influence on mining production, as well as the uncontrollable inversion period and accuracy of the target area during the passive seismic tomography, an optimization algorithm based on adding
Xinyuan Tian, Siyuan Gong, Linming Dou, Shun Hu, Bengang Chen, Qiang Lu   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

An optimized modeling for in-situ stresses based on Rhino accurate modeling and large-scale transverse isotropic theory

Scientific Reports, 2023
In-situ stresses are significantly important for underground mining geotechnical design and coal seam gas management in underground coal mines. Aiming at regions with geological structures, this paper proposes an in-situ stress inversion method combining
Weihua Song, Huice Jiao, Xiaotian Xu, Ping He   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Co and postseismic fault slip models of the 2022 MW6.7 Menyuan earthquake reveal conjugated faulting tectonics at the central section of the Lenglongling fault[Key points]

Earthquake Science
The 2022 MW6.7 Menyuan earthquake ruptured the western end of the Tianzhu seismic gap, providing an opportunity to study the regional seismogenic characteristics and seismic hazards.
Zilong He, Wenbin Xu, Zhiwei Li, Lei Xie, Guangcai Feng, Nan Fang, Xiaoge Liu, Kai Sun, Zhidan Chen, Zhihui Zhu   +9 more
doaj   +1 more source

Inversion Analysis of the In Situ Stress Field around Underground Caverns Based on Particle Swarm Optimization Optimized Back Propagation Neural Network

Applied Sciences, 2023
The in situ stress distribution is one of the driving factors for the design and construction of underground engineering. Numerical analysis methods based on artificial neural networks are the most common and effective methods for in situ stress ...
Hong-Chuan Yan, Huai-Zhong Liu, Yao Li, Li Zhuo, Ming-Li Xiao, Ke-Pu Chen, Jia-Ming Wu, Jian-Liang Pei   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source