Results 41 to 50 of about 51,262 (257)

Stress triggering mechanism of strong mine earthquake in huge thick strata revealed by inversion of joint source rupture information

Meitan xuebao
Under the condition of unconformable deposition of the Cretaceous Zhidan Group huge thick strata in the Inner Mongolia-Shanxi mining area, frequent occurrence of strong mine earthquake (SME) during deep mining, resulting in tremors at the surface，has ...
Yao YANG, Anye CAO, Yaoqi LIU, Xianxi BAI, Changbin WANG, Chengchun XUE, Qiang WANG   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Determining the stress field in active volcanoes using focal mechanisms

Frontiers in Earth Science, 2016
Stress inversion of seismological datasets became an essential tool to retrieve the stress field of active tectonics and volcanic areas. In particular, in volcanic areas, it is able to put constrains on volcano-tectonics and in general in a better ...
Bruno Massa, Bruno Massa, Luca D'Auria, Luca D'Auria, Elena Cristiano, Ada De Matteo   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Theoretical and Experimental Study on Parameter Optimization of Active Sources in Seismic Tomography [PDF]

Lithosphere
Given the high cost of active seismic tomography and the large influence on mining production, as well as the uncontrollable inversion period and accuracy of the target area during the passive seismic tomography, an optimization algorithm based on adding
Xinyuan Tian, Siyuan Gong, Linming Dou, Shun Hu, Bengang Chen, Qiang Lu   +5 more
doaj   +1 more source

An optimized modeling for in-situ stresses based on Rhino accurate modeling and large-scale transverse isotropic theory

Scientific Reports, 2023
In-situ stresses are significantly important for underground mining geotechnical design and coal seam gas management in underground coal mines. Aiming at regions with geological structures, this paper proposes an in-situ stress inversion method combining
Weihua Song, Huice Jiao, Xiaotian Xu, Ping He   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Inversion Analysis of the In Situ Stress Field around Underground Caverns Based on Particle Swarm Optimization Optimized Back Propagation Neural Network

Applied Sciences, 2023
The in situ stress distribution is one of the driving factors for the design and construction of underground engineering. Numerical analysis methods based on artificial neural networks are the most common and effective methods for in situ stress ...
Hong-Chuan Yan, Huai-Zhong Liu, Yao Li, Li Zhuo, Ming-Li Xiao, Ke-Pu Chen, Jia-Ming Wu, Jian-Liang Pei   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Co and postseismic fault slip models of the 2022 MW6.7 Menyuan earthquake reveal conjugated faulting tectonics at the central section of the Lenglongling fault[Key points]

Earthquake Science
The 2022 MW6.7 Menyuan earthquake ruptured the western end of the Tianzhu seismic gap, providing an opportunity to study the regional seismogenic characteristics and seismic hazards.
Zilong He, Wenbin Xu, Zhiwei Li, Lei Xie, Guangcai Feng, Nan Fang, Xiaoge Liu, Kai Sun, Zhidan Chen, Zhihui Zhu   +9 more
doaj   +1 more source