Results 51 to 60 of about 2,967,034 (250)

Three-dimensional tomographic inversion of combined reflection and refraction seismic travel-time data

, 2003
A tomographic inversion method is presented for the determination of 3-D velocity and interface structure from a wide range of body-wave seismic traveltime data types.
T. A. Minshull, Minshull, Ta, J. W. D. Hobro, Singh, Sc, S. C. Singh, Hobro, Jwd, Minshull, T.A., Hobro, J.W.D., Singh, S.C.   +8 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Propagator and wave-equation inversion for near-receiver material properties [PDF]

, 2004
Near-receiver material properties are required for the separation of the recorded wavefield into upgoing and downgoing P and S waves, and are also important for static time-shift corrections.
Trampert, J., Curtis, A.; id_orcid, van Vossen, R.   +2 more
core   +1 more source

Co and postseismic fault slip models of the 2022 MW6.7 Menyuan earthquake reveal conjugated faulting tectonics at the central section of the Lenglongling fault[Key points]

Earthquake Science
The 2022 MW6.7 Menyuan earthquake ruptured the western end of the Tianzhu seismic gap, providing an opportunity to study the regional seismogenic characteristics and seismic hazards.
Zilong He, Wenbin Xu, Zhiwei Li, Lei Xie, Guangcai Feng, Nan Fang, Xiaoge Liu, Kai Sun, Zhidan Chen, Zhihui Zhu   +9 more
doaj   +1 more source

An optimized modeling for in-situ stresses based on Rhino accurate modeling and large-scale transverse isotropic theory

Scientific Reports, 2023
In-situ stresses are significantly important for underground mining geotechnical design and coal seam gas management in underground coal mines. Aiming at regions with geological structures, this paper proposes an in-situ stress inversion method combining
Weihua Song, Huice Jiao, Xiaotian Xu, Ping He   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Research on In Situ Stress Measurement Based on the Combined Method of DIC and Drilling Stress Relief

Buildings
Existing structural stress is an important parameter for evaluating the current state of a structure. In order to improve the accuracy of in situ stress measurement in the field, this paper proposes an in situ stress measurement method for existing ...
Lingting Ye, Liping Chen, Peng Zhao, Ruichuan Zhao, Yixiang Zhou   +4 more
doaj   +1 more source

Inversion Analysis of the In Situ Stress Field around Underground Caverns Based on Particle Swarm Optimization Optimized Back Propagation Neural Network

Applied Sciences, 2023
The in situ stress distribution is one of the driving factors for the design and construction of underground engineering. Numerical analysis methods based on artificial neural networks are the most common and effective methods for in situ stress ...
Hong-Chuan Yan, Huai-Zhong Liu, Yao Li, Li Zhuo, Ming-Li Xiao, Ke-Pu Chen, Jia-Ming Wu, Jian-Liang Pei   +7 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source