Results 61 to 70 of about 2,967,034 (250)

Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress [PDF]

, 2010
Recent findings indicate that endoplasmic reticulum (ER) stress is significantly increased in adipose tissue of obese human subjects and is critical to the initiation and integration of pathways of inflammation and insulin action.
Saif Alhusaini, Harte, A., McGee, K., Gyanendra Tripathi, Kumar, Sudhesh, Tripathi, Gyanendra, Sudhesh Kumar, Alhusaini, S., McTernan, P. G., Harte, A. L., McTernan, P., Bruno Schisano, Philip McTernan, Schisano, B., McGee, K. C., Kumar, S., Alison Harte, Tripathi, G., Kirsty McGee   +18 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Kalman Inversion Stress Microscopy [PDF]

, 2018
23 pages, 8 pagesInternational audienceAlthough mechanical cues are crucial to tissue morphogenesis and development, the tissue mechanical stress field remains poorly characterized.
Peyret, G., d'Alessandro, J., Ishihara, S., Marcq, P., Ladoux, B., Nier, V.   +5 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A Deep Neural Network for Acoustic-Articulatory Speech Inversion [PDF]

, 2011
In this work, we implement a deep belief network for the acoustic-articulatory inversion mapping problem. We find that adding up to 3 hidden-layers improves inversion accuracy.
Renals, S., Richmond, K.; id_orcid, Uria, Benigno   +2 more
core  

Tensile–shear microcrack source mechanism and stress inversion methods of coal–rock

Meitan xuebao
Precise monitoring and quantitative inversion of coal–rock fracture geometries and stress‐field distributions are regarded as fundamental scientific prerequisites for elucidating the evolution of rockburst processes and associated failure mechanisms, and
Enyuan WANG, Li ZHANG, Xiaoran WANG, Xiaofei LIU, Nan LI   +4 more
doaj   +1 more source

Syndesmotic instability can be assessed by measuring the distance between the tibia and the fibula using an ultrasound without stress: a cadaver study

BMC Musculoskeletal Disorders, 2022
Background Ultrasound examinations for syndesmosis injury might be useful for the quantitative evaluation of syndesmotic instability. The purpose of this study was to evaluate the efficacy of ultrasound assessment by measuring the tibiofibular distance ...
Hiroaki Shoji, Atsushi Teramoto, Yasutaka Murahashi, Kota Watanabe, Toshihiko Yamashita   +4 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Investigation of stress-strain behavior of calcareous sand sites using a novel integrated inversion analysis framework

The stress-strain behavior of soil is a fundamental indicator for understanding failure mechanisms and deformation patterns. In earthquake engineering and soil dynamics, it serves as a key basis for characterizing the dynamic properties of sand sites ...
Wu, Yang, Shiau, Jim, Cai, Jindou, Cui, Jie, Zhu, Fan, Zhang, Xiaoyu, Ding, Ruiyang   +6 more
core   +1 more source

MULTIBASELINE POLARIMETRIC SAR INTERFEROMETRY FOREST HEIGHT INVERSION APPROACHES [PDF]

, 2011
Polarimetric SAR interferometry (Pol-InSAR) is a radar remote sensing technique that is sensitive to the vertical distribution of scattering processes in volumes.
Lee, Seung-Kuk, Hajnsek, Irena, Kugler, Florian, Papathanassiou, Konstantinos   +3 more
core