Results 91 to 100 of about 3,042,639 (351)

Changes in wave climate over the northwest European shelf seas during the last 12,000 years

, 2009
Because of the depth attenuation of wave orbital velocity, wave-induced bed shear stress is much more sensitive to changes in total water depth than tidal-induced bed shear stress.
Austin, Barrow, Beets, Belderson, Berger, Booij, Boulton, Böse, Cameron, Carr, Carter, Draper, Elliott, G. R. Bigg, Hinton, Hinton, Hurrell, J. D. Scourse, K. Uehara, Komen, Lambeck, Lambeck, Lambeck, Lambeck, Milne, Mitrovica, Neill, Neill, Newell, Ogston, Palutikof, Peltier, Peltier, Pingree, Renssen, Reynaud, Rippeth, Ris, S. P. Neill, Scourse, Simmons, Uehara, van der Molen, van der Molen, van der Molen, Vincent   +45 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Influence of linear profile modification and loading conditions on the dynamic tooth load and stress of high contact ratio gears [PDF]

A computer simulation for the dynamic response of high-contact-ratio spur gear transmissions is presented. High contact ratio gears have the potential to produce lower dynamic tooth loads and minimum root stress but they can be sensitive to tooth profile
Lee, Chinwai, Lin, Hsiang Hsi, Oswald, Fred B., Townsend, Dennis P.   +3 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Fatigue Characteristics of 7050-T7451 Aluminum Alloy Friction Stir Welding Joints and the Stress Ratio Effect. [PDF]

Materials (Basel), 2022
Zhu H, Lacidogna G, Deng C, Gong B, Liu F.   +4 more
europepmc   +1 more source

Stress Testing of Probability of Default of Individuals [PDF]

This paper introduces a model for stress testing of probability of default of individuals. The model rests on assumption that the individual defaults if his savings fall below zero.
Aleš Slabý, Josef Vodička, Petr Kadeřábek   +2 more
core   +1 more source

Stress distribution and the fragility of supercooled melts

, 2010
We formulate a minimal ansatz for local stress distribution in a solid that includes the possibility of strongly anharmonic short-length motions. We discover a broken-symmetry metastable phase that exhibits an aperiodic, frozen-in stress distribution ...
Abramowitz A., Angell C. A., Bales G. S., Casalini R., Cochran W., Grannan E. R., Hall R., Hall R. W., Johari G. P., Kirkpatrick T. R., Kirkpatrick T. R., Kirkpatrick T. R., Landau L. D., Lindemann F. A., Loidl A., Lookman T., Lubchenko V., Lubchenko V., Lubchenko V., Lubchenko V., Lubchenko V., Lubchenko V., Luttinger J. M., Mandel J., Martinez L.-M., Mehrabadi M. M., Monasson R., Nobre F. D., Novikov V. N., Novikov V. N., Rowlinson J. S., Schmalian J., Singh Y., Sokolov A. P., Stevenson J., Stevenson J. D., Torchinsky D. H., Turnbull D., Usatenko Z. E., Xia X., Yannopoulos N., Yu C. C.   +41 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Modeling the Effect of Stress Ratio, Loading Frequency and Fiber Orientation on the Fatigue Response of Composite Materials. [PDF]

Polymers (Basel), 2022
Ma H, Bai X, Ran Y, Wei X, An Z.
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source