Results 101 to 110 of about 3,048,656 (303)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Stress Testing of Probability of Default of Individuals [PDF]

This paper introduces a model for stress testing of probability of default of individuals. The model rests on assumption that the individual defaults if his savings fall below zero.
Aleš Slabý, Josef Vodička, Petr Kadeřábek   +2 more
core   +1 more source

Changes in wave climate over the northwest European shelf seas during the last 12,000 years

, 2009
Because of the depth attenuation of wave orbital velocity, wave-induced bed shear stress is much more sensitive to changes in total water depth than tidal-induced bed shear stress.
Austin, Barrow, Beets, Belderson, Berger, Booij, Boulton, Böse, Cameron, Carr, Carter, Draper, Elliott, G. R. Bigg, Hinton, Hinton, Hurrell, J. D. Scourse, K. Uehara, Komen, Lambeck, Lambeck, Lambeck, Lambeck, Milne, Mitrovica, Neill, Neill, Newell, Ogston, Palutikof, Peltier, Peltier, Pingree, Renssen, Reynaud, Rippeth, Ris, S. P. Neill, Scourse, Simmons, Uehara, van der Molen, van der Molen, van der Molen, Vincent   +45 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Discrete dislocation dynamics simulations of dislocation-$\theta'$ precipitate interaction in Al-Cu alloys

, 2018
The mechanisms of dislocation/precipitate interaction were studied by means of discrete dislocation dynamics within a multiscale approach. Simulations were carried out using the discrete continuous method in combination with a fast Fourier transform ...
Capolungo, L., Esteban-Manzanares, G., LLorca, J., Papadimitriou, I., Santos-Güemes, R., Segurado, J.   +5 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Stress distribution and the fragility of supercooled melts

, 2010
We formulate a minimal ansatz for local stress distribution in a solid that includes the possibility of strongly anharmonic short-length motions. We discover a broken-symmetry metastable phase that exhibits an aperiodic, frozen-in stress distribution ...
Abramowitz A., Angell C. A., Bales G. S., Casalini R., Cochran W., Grannan E. R., Hall R., Hall R. W., Johari G. P., Kirkpatrick T. R., Kirkpatrick T. R., Kirkpatrick T. R., Landau L. D., Lindemann F. A., Loidl A., Lookman T., Lubchenko V., Lubchenko V., Lubchenko V., Lubchenko V., Lubchenko V., Lubchenko V., Luttinger J. M., Mandel J., Martinez L.-M., Mehrabadi M. M., Monasson R., Nobre F. D., Novikov V. N., Novikov V. N., Rowlinson J. S., Schmalian J., Singh Y., Sokolov A. P., Stevenson J., Stevenson J. D., Torchinsky D. H., Turnbull D., Usatenko Z. E., Xia X., Yannopoulos N., Yu C. C.   +41 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Crack Growth Analytical Model Considering the Crack Growth Resistance Parameter Due to the Unloading Process

Aerospace
Crack growth analysis is essential for probabilistic damage tolerance assessment of aeroengine life-limited parts. Traditional crack growth models directly establish the stress ratio–crack growth rate or crack opening stress relationship and focus less ...
Guo Li, Shuchun Huang, Zhenlei Li, Wanqiu Lu, Shuiting Ding, Rong Chen, Fan Cao   +6 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source