Results 71 to 80 of about 2,417,663 (337)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Identification of nuclear membrane SUN proteins and components associated with wheat fungal stress responses

Stress Biology
In eukaryotes, the nuclear membrane that encapsulates genomic DNA is composed of an inner nuclear membrane (INM), an outer nuclear membrane (ONM), and a perinuclear space.
Huan Guo, Jianfeng Wang, Di Yao, Ligang Yu, Wenting Jiang, Lincai Xie, Shikai Lv, Xiangyu Zhang, Yajuan Wang, Changyou Wang, Wanquan Ji, Hong Zhang   +11 more
doaj   +1 more source

OsSCYL2 is Involved in Regulating ABA Signaling-Mediated Seed Germination in Rice

Plants
Seed germination represents a multifaceted biological process influenced by various intrinsic and extrinsic factors. In the present study, our investigation unveiled the regulatory role of OsSCYL2, a gene identified as a facilitator of seed germination ...
Minyan Xu, Wei Zhang, Yuhuan Jiao, Qing Yang, Meng Chen, Hu Cheng, Beijiu Cheng, Xin Zhang   +7 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Identification of the ZmATG18 subfamily genes in maize and the role of ZmATG18a in drought stress

BMC Genomics
Background Autophagy represents an ancient cytoprotective program that sustains cell viability under metabolic or environmental stresses via targeted recycling of cellular components. However, the contribution of ATG18s in maize is ambiguous.
Ziming Wang, Feiyan Luo, Cheng Meng, Jihao Si, Wenzhi Zhang, Jiahao Sun, Zhe Wang   +6 more
doaj   +1 more source

On giant piezoresistance effects in silicon nanowires and microwires

, 2010
The giant piezoresistance (PZR) previously reported in silicon nanowires is experimentally investigated in a large number of surface depleted silicon nano- and micro-structures.
Arscott, S., Milne, J. S., Renner, C., Rowe, A. C. H.   +3 more
core   +5 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

ClPS1 gene-mediated manipulation of 2n pollen formation enables the creation of triploid seedless watermelon

Molecular Horticulture
Seedless watermelons are increasingly dominating the consumer market due to their convenience and high quality. However, traditional triploid watermelon breeding faces challenges such as long breeding cycles and low survival rates of triploid F1 progeny,
Wenyu Pang, Qiaran Wang, Chenxin Li, Wenbing He, Jiafa Wang, Shujuan Tian, Li Yuan   +6 more
doaj   +1 more source

Crack path selection at the interface of wrought and wire+arc additive manufactured Ti–6Al–4V [PDF]

, 2016
Crack propagation deviation tendency in specimens containing an interface between wrought alloy substrate and Wire + Arc Additive Manufacture (WAAM) built Ti–6Al–4V is investigated from the viewpoints of microstructure, residual stress and bi-material ...
Addison, Antonysamy, Antonysamy, ASTM, Baufeld, Baufeld, Brandl, Brandl, Colegrove, Dahlin, Dattoma, Ding, Edwards, Edwards, Edwards, Evans, Fan, Frazier, Hills, Irwin, Kelly, Leuders, Lorant, Martina, Mok, Nègre, Paradowska, Peters, Pippan, Prime, Prime, Rangaswamy, Schroeder, Taminger, Van Hooreweder, Wang, Wang, Zhang, Zhang, Zhu   +39 more
core   +3 more sources