Results 231 to 240 of about 9,396,325 (306)

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

The integrated stress response in pancreatic β-cell failure in diabetes: from molecular mechanisms to precision therapeutics. [PDF]

Front Endocrinol (Lausanne)
Huang Y, Zeng Y, Zhong X, Li L.
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

MANF in the lateral septum dynamically regulates endoplasmic reticulum function in chronic stress response. [PDF]

Transl Psychiatry
Ye J, Duan C, Pei H, Weng J, Wang W, Xu J, Li Y, Yuan T, Peng D.   +8 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Extracellular vesicles as indicators of environmental stress response in <i>Lactiplantibacillus plantarum</i>. [PDF]

Extracell Vesicles Circ Nucl Acids
Razim A, Laimer-Digruber A, Schmid AM, Edelbacher TV, Paschall ME, Weinmayer T, Thaler M, Kebreab R, Skalska ME, Migdał P, Morandi M, Daniel C, Srutkova D, Schwarzer M, Hrdy J, Ehling-Schulz M, Górska S, Inic-Kanada A, Wiedermann U, Schabussova I.   +19 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Estrogen receptors and the NRF2 pathway: bridging hormonal regulation and stress response in the gut. [PDF]

Front Endocrinol (Lausanne)
Kopacz A, Tomaszewska Z, Piechota-Polanczyk A.   +2 more
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

The MFS transporter BcTpo1 governs the oxidative stress response and infection of Botrytis cinerea. [PDF]

Crop Health
Wang L, Xie Y, Li J, Yang F, Liang W, Yang Q.   +5 more
europepmc   +1 more source