Results 251 to 260 of about 4,906,635 (333)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

RAF inhibitors activate the integrated stress response by direct activation of GCN2. [PDF]

Nat Commun
Gilley R, Kidger AM, Neill G, Morrison E, Severson P, Byrne DP, Kenneth NS, Bollag G, Zhang C, Maia de Oliveira T, Eyers PA, Bayliss R, Masson GR, Cook SJ.   +13 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Epromoters bind key stress-related transcription factors to regulate clusters of stress response genes. [PDF]

EMBO J
Malfait J, Wan J, Singh HN, Souaid C, Farah G, Su J, Torres M, Manosalva I, Sakakini N, Esnault C, Sarrazin S, Sieweke M, Spicuglia S.   +12 more
europepmc   +1 more source

Integrated physiological, transcriptomic and widely targeted metabolomic analyses reveal the underlying mechanism of cold stress response in the panicle apical abortion line J876 derived from Oryza rufipogon

Chengkai Lu, Jinglin Wu, Jiazhi Liu, Xi Xu, Deyu Zhang, Amir Sohail, Xinyu Mao, Jinpeng Wan, Guizhou Liu, Peng Xu   +9 more
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Mitochondrial stress response in lung cells triggered by the inhaled nanoplastics. [PDF]

Arch Toxicol
Siemiątkowska B, Szczepanowska J.
europepmc   +1 more source

Microplastics from biodegradable plastic bags alter soil properties and trigger stress response in sunflowers

Anita Jemec Kokalj, Teja Pelko, Jure Mravlje, Gabriela Kalčíková, Tina Skalar, Andrej Kržan, Marjana Regvar, Mark Starin, Vogel-Mikus Katarina   +8 more
openalex   +1 more source

CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans

, 2018
Yujie Li, Sandra Finkbeiner, Athina Ganner, Julia P. Gerber, Marinella Klein, Manuel Grafe, Jakob Kandzia, Antje Thien, Kathrin Thedieck, G. Breves, Thomas Jank, Ralf Baumeister, Gerd Walz, Elke Neumann‐Haefelin   +13 more
openalex   +2 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source