Results 21 to 30 of about 1,987,084 (313)

CiAPEX2 and CiP0, candidates of AP endonucleases in Ciona intestinalis, have 3′-5′ exonuclease activity and contribute to protection against oxidative stress

Genes and Environment, 2017
Apurinic/apyrimidinic (AP) sites are one of the most frequent DNA lesions. AP sites inhibit transcription and DNA replication, and induce cell death. AP endonucleases are key enzymes in AP site repair. Several types of AP endonucleases have been reported,
Masafumi Funakoshi, Daisuke Nambara, Yuichiro Hayashi, Qiu-Mei Zhang-Akiyama   +3 more
doaj   +1 more source

Revealing the Variation and Stability of Bacterial Communities in Tomato Rhizosphere Microbiota

Microorganisms, 2020
Microorganisms that colonize the plant rhizosphere can contribute to plant health, growth and productivity. Although the importance of the rhizosphere microbiome is known, we know little about the underlying mechanisms that drive microbiome assembly and ...
Zhiqiang Cheng, Shaonan Lei, Ye Li, Wei Huang, Rongqin Ma, Juan Xiong, Ting Zhang, Lingyue Jin, Hafeez ul Haq, Xiaohong Xu, Baoyu Tian   +10 more
doaj   +1 more source

Natural Compounds That Enhance Motor Function in a Mouse Model of Muscle Fatigue

Biomedicines, 2022
Musculoskeletal disease can be a serious condition associated with aging that may lead to fractures and a bedridden state due to decreased motor function.
Shuichi Shibuya, Kenji Watanabe, Daiki Sakuraba, Takuya Abe, Takahiko Shimizu   +4 more
doaj   +1 more source

Prophages and Growth Dynamics Confound Experimental Results with Antibiotic-Tolerant Persister Cells

mBio, 2017
Bacterial persisters are phenotypic variants that survive antibiotic treatment in a dormant state and can be formed by multiple pathways. We recently proposed that the second messenger (p)ppGpp drives Escherichia coli persister formation through protease
Alexander Harms, Cinzia Fino, Michael A. Sørensen, Szabolcs Semsey, Kenn Gerdes   +4 more
doaj   +1 more source

PasT of Escherichia coli sustains antibiotic tolerance and aerobic respiration as a bacterial homolog of mitochondrial Coq10

MicrobiologyOpen, 2020
Antibiotic‐tolerant persisters are often implicated in treatment failure of chronic and relapsing bacterial infections, but the underlying molecular mechanisms have remained elusive.
Cinzia Fino, Martin Vestergaard, Hanne Ingmer, Fabien Pierrel, Kenn Gerdes, Alexander Harms   +5 more
doaj   +1 more source

Screening for functional IRESes using α-complementation system of β-galactosidase in Pichia pastoris

Biotechnology for Biofuels, 2019
Background Pichia pastoris is becoming a promising chassis cell for metabolic engineering and synthetic biology after its whole genome and transcriptome sequenced. However, the current systems for multigene co-expression in P. pastoris are not efficient.
Yide Huang, Yafei Zhang, Suhuan Li, Ting Lin, Jingwen Wu, Yao Lin   +5 more
doaj   +1 more source

Estimation of the Number of General Anesthesia Cases Based on a Series of Nationwide Surveys on Twitter during COVID-19 Pandemic in Japan: A Statistical Analysis

Medicina, 2021
Background and objectives: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread to more than 200 countries.
Yosuke Fujii, Hiroki Daijo, Kiichi Hirota   +2 more
doaj   +1 more source

5-Methylindole Potentiates Aminoglycoside Against Gram-Positive Bacteria Including Staphylococcus aureus Persisters Under Hypoionic Conditions

Frontiers in Cellular and Infection Microbiology, 2020
Antibiotic resistance/tolerance has become a severe threat to human and animal health. To combat antibiotic-resistant/tolerant bacteria, it is of significance to improve the efficacy of traditional antibiotics.
Fengqi Sun, Mengmeng Bian, Zhongyan Li, Boyan Lv, Yuanyuan Gao, Yuanyuan Gao, Yan Wang, Xinmiao Fu, Xinmiao Fu   +8 more
doaj   +1 more source

The α-mating factor secretion signals and endogenous signal peptides for recombinant protein secretion in Komagataella phaffii

Biotechnology for Biofuels and Bioproducts, 2022
Background The budding yeast Komagataella phaffii (Pichia pastoris) is widely employed to secrete proteins of academic and industrial interest.
Chenwei Zou, Lingfang Lu, Shengyan Wang, Chenshan Zhang, Xuequn Chen, Yao Lin, Yide Huang   +6 more
doaj   +1 more source

A pilot cross-sectional investigation of chronic shame as a mediator of the relationship between subjective social status and self-rated health among middle-aged adults

Health Psychology and Behavioral Medicine, 2023
Subjective social status (SSS) is an important independent predictor of health outcomes, however, the pathways through which it affects health are poorly understood.
Ellen C. McGarity-Shipley, Eun-Young Lee, Kyra E. Pyke   +2 more
doaj   +1 more source