Results 161 to 170 of about 4,522,899 (285)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Analyses of Stress-State-Dependent Ductile Damage and Fracture Behavior of Zirconium. [PDF]

open access: yesMaterials (Basel)
Pan B   +5 more
europepmc   +1 more source

Skin-to-skin contact to improve premature mothers' anxiety and stress state: A meta-analysis. [PDF]

open access: yesMatern Child Nutr, 2021
Cong S   +8 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Enhancing EEG-Based Mental Stress State Recognition Using an Improved Hybrid Feature Selection Algorithm. [PDF]

open access: yesSensors (Basel), 2021
Hag A   +6 more
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

open access: yesMolecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya   +2 more
wiley   +1 more source

The Influence of Cement Layer Thickness on the Stress State of Metal Inlay Restorations-Photoelastic Analysis. [PDF]

open access: yesMaterials (Basel), 2021
Sokolowski G   +5 more
europepmc   +1 more source

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