Results 101 to 110 of about 239,259 (304)
Mimetics of Hormetic Agents: Stress-Resistance Triggers
Dose-Response, 2010 Mimetics of hormetic agents offer a novel approach to adjust dose to minimize the risk of toxic response, and maximize the benefit of induction of at least partial physiological conditioning. Nature selected and preserved those organisms and triggers that promote tolerance to stress.
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Alternative Strategy for Alzheimer’s Disease: Stress Response Triggers [PDF]
International Journal of Alzheimer's Disease, 2012 Stress resistance capacity is a hallmark of longevity protection and survival throughout the plant and animal kingdoms. Latent pathway activation of protective cascades, triggered by environmental challenges to tolerate heat, oxygen deprivation, reactive oxygen species (ROS), diet restriction, and exercise provides tolerance to these stresses.
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Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Scientific ReportsUnderstanding earthquake nucleation is vital for predicting and mitigating seismic events, saving lives, and enhancing construction practices in earthquake-prone areas.
Sheng Hua Ye +2 more
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Tidal Triggering of Earthquakes [PDF]
, 1975 Analysis of the tidal stress tensor at the time of moderate to large earthquakes strongly suggests that shallow (< 30 km) larger magnitude oblique-slip and dip-slip earthquakes are triggered by tidal stresses.
Heaton, Thomas H.
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Malignant hyperthermia — Human stress triggering
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011 AbstractLetter to the Editor concerns the question of a discussion of awake porcine malignant hyperthermia that erroneously omits the awake human stress reaction of malignant hyperthermia.
Gronert, Gerald A. +2 more
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
The role of triggering by static stress transfer during geothermal reservoir stimulation
, 2012 International audienceDuring creation of an Enhanced Geothermal System, massive fluid injections are conducted to induce fracture shear which generates reservoir permeability.
Dorbath, L. +7 more
core +1 more source