Results 101 to 110 of about 3,038,437 (295)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Insights on earthquake nucleation revealed by numerical simulation and unsupervised machine learning of laboratory-scale earthquake

Scientific Reports
Understanding earthquake nucleation is vital for predicting and mitigating seismic events, saving lives, and enhancing construction practices in earthquake-prone areas.
Sheng Hua Ye, Semechah K. Y. Lui, R. Paul Young   +2 more
doaj   +1 more source

Emotional triggering and low socio-economic status as determinants of depression following acute coronary syndrome [PDF]

, 2011
BackgroundThe determinants of depression following acute coronary syndrome (ACS) are poorly understood. Triggering of ACS by emotional stress and low socio-economic status (SES) are predictors of adverse outcomes.
Randall, Gemma, Kaski, J C, Messerli-Bürgy, Nadine, G. J. Molloy, Wikman, Anna, Steptoe, A, Perkins-Porras, Linda, G. Randall, J. C. Kaski, Messerly-Bürgy, N, Wikman, Anna,, N. Messerly-Bürgy, Steptoe, Andrew, Molloy, G J, Perkins-Porras, L, Kaski, Juan Carlos, A. Steptoe, A. Wikman, Randall, G, L. Perkins-Porras, Molloy, Gerry J.   +20 more
core   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Alternative Strategy for Alzheimer’s Disease: Stress Response Triggers [PDF]

International Journal of Alzheimer's Disease, 2012
Stress resistance capacity is a hallmark of longevity protection and survival throughout the plant and animal kingdoms. Latent pathway activation of protective cascades, triggered by environmental challenges to tolerate heat, oxygen deprivation, reactive oxygen species (ROS), diet restriction, and exercise provides tolerance to these stresses.
openaire   +2 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Skin TLR7 triggering promotes accumulation of respiratory dendritic cells and natural killer cells. [PDF]

, 2012
The TLR7 agonist imiquimod has been used successfully as adjuvant for skin treatment of virus-associated warts and basal cell carcinoma. The effects of skin TLR7 triggering on respiratory leukocyte populations are unknown.
Lohmeyer, Jürgen, Werner von Wulffen (141047), Gruber, Achim D., Gregor Bein (141053), Knoche, Angela, Kershaw, Olivia, Kranz, Sabine, Angela Knoche (141037), Holger Hackstein (141030), Hagel, Nicole, Angela Knoche, Wulffen, Werner von, Olivia Kershaw (141049), Holger Hackstein, Olivia Kershaw, Achim D. Gruber (141051), Nicole Hagel, Gregor Bein, Jürgen Lohmeyer, Sabine Kranz, Nicole Hagel (141033), Baal, Nelli, Bein, Gregor, Achim D Gruber, Jürgen Lohmeyer (141044), Nelli Baal (141055), Hackstein, Holger, Nelli Baal, Werner von Wulffen, Sabine Kranz (141040)   +29 more
core   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Adolescent girls' experiences of underlying social processes triggering stress in their everyday life: a grounded theory study

, 2011
The aim of this study was to generate a theoretical model of underlying social processes that trigger stress in adolescent girls' everyday life. In-depth interviews regarding the experiences of stress at home, school and during leisure time were ...
Lindgren, Eva-Carin,, Marklund, B,, Bengt Fridlund, Haraldsson, Katarina,, Lindgren, E-C,, Marklund, Bertil,, Eva-Carin Lindgren, Mattsson, B,, Bertil Marklund, Fridlund, Bengt,, Mattsson, Bengt,, Bengt Mattsson, Haraldsson, K,, Katarina Haraldsson   +13 more
core   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source