Results 91 to 100 of about 3,038,437 (295)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The static stress change triggering model: Constraints from two southern California aftershock sequences [PDF]
, 1998 Static stress change has been proposed as a mechanism of earthquake triggering. We quantitatively evaluate this model for the apparent triggering of aftershocks by the 1992 M_W 7.3 Landers and 1994 M_W 6.7 Northridge earthquakes.
Hauksson, Egill +2 more
core
, 2000 International audienceThis paper concentrates on the problem of fault interaction and earthquake triggering through the 1980 Irpinia, Italy, sequence. More specifically, this paper deals with the problem of the triggering of the second subevent by the ...
Ionescu, Ioan, R. +10 more
core +1 more source
A parametric study of the numerical simulations of triggered VLF emissions [PDF]
, 2005 This work is concerned with the numerical modelling of VLF emissions triggered in the equatorial region of the Earth’s magnetosphere, using a well established 1D Vlasov Hybrid Simulation (VHS) code.
Rycroft, M. +8 more
core +2 more sources
Identifying asynchronies: work shifting and double triggering
, 2022 Mechanical ventilation supports the work of breathing, improves gas exchange, and unloads the respiratory muscles, all of which require good synchronization between the patient and the ventilator.
Jamille Pasco, Víctor Perez
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Acute myocardial infarction triggered by emotional stress
The American Journal of Cardiology, 1992 Abstract Myocardial infarction has been shown to have a circadian pattern of occurrence, with a significantly increased incidence in the early morning hours. 1 Recognition that onset of acute coronary syndromes may not occur as a random event has led investigators to search for triggers of myocardial infarction.
M D, Gelernt, J S, Hochman
openaire +2 more sources
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Oxidative stress in genetic mouse models of Parkinson's disease [PDF]
, 2012 There is extensive evidence in Parkinson’s disease of a link between oxidative stress and some of the monogenically inherited Parkinson’s disease-associated genes.
Bentea, Eduard +3 more
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source