Results 81 to 90 of about 239,259 (304)

Stress-Triggered Changes in Peripheral Catecholaminergic Systems [PDF]

, 2013
The sympathetic nervous system not only regulates cardiovascular and metabolic responses to stress but also is altered by stress. The sympathoneural and sympathoadrenomedullary systems are modified by different metabolic pathways and have different responses to short- and to long-term stressors.
Kvetnansky, Richard, Lu, Xiaojiong, Ziegler, Michael G   +2 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Role of Tectonic Stress in Triggering Large Silicic Caldera Eruptions

, 2018
Data presented are the results of numerical experiments to address the affect of tectonic stress on the mechanics of triggering caldera-forming volcanic ...
Haley E. Cabaniss, Patricia M Gregg (8023781), Grosfils, Eric B, Patricia M. Gregg, Eric B Grosfils (8054252), Cabaniss, Haley E, Eric B. Grosfils, Gregg, Patricia M, Haley E Cabaniss (8054249)   +8 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Natural Antioxidants and Aquatic Animal Health

Antioxidants
In intensive aquaculture, aquatic animals inevitably encounter multiple stressors due to environmental fluctuations, triggering various stress responses, with oxidative stress being the most prevalent [...]
Rui Jia
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Adsorption of antimicrobial peptide onto chitosan-coated iron oxide nanoparticles fosters oxidative stress triggering bacterial cell death. [PDF]

RSC Adv, 2023
Leena Panigrahi L, Shekhar S, Sahoo B, Arakha M.   +3 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Tremor burst and triggering processes in Cascadia after the 2022 Hunga Tonga-Hunga Ha’apai volcanic eruption

Geomatics, Natural Hazards & Risk
Episodic Tremors and Slip (ETS) are highly susceptible and sensitive to external stress perturbations. The tidal and remote triggering phenomena of tremors are well-documented globally, however, the significance of the delayed triggering mechanism ...
Sambit Sahoo, Batakrushna Senapati, Bhaskar Kundu, Yijian Zhou, Abhijit Ghosh, Shuanggen Jin   +5 more
doaj   +1 more source

Static Stress Transfer between the Chinshan and Shanchiao Faults in the Taipei Metropolitan Area

Terrestrial, Atmospheric and Oceanic Sciences, 2010
In the Taipei Metropolitan Area, there is a significant problem to be resolved: Can two major active faults, i.e., the Chinshan and Shanchiao faults fail simultaneously? The two faults are both normal faulting based upon recent observations.
Jeng-Cheng Wang, Jeen-Hwa Wang, Chiou-Fen Shieh, Yih-Hsiung Yeh   +3 more
doaj   +1 more source