Results 101 to 110 of about 1,921,038 (288)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Nauka ta progres transportu, 2008 On the basis of laboratory explorations the features of conducting the corrosive process in the shaft reinforcement parts under the load from lifting buckets and rock mass were determined.
V. V. Kovalenko +3 more
doaj
Tectonic-structural systems of Mars: Is it possible to use them to reconstruct its thermal evolution? [PDF]
Geofísica Internacional, 2004 This work tries to establish the possible relationship among cortical stresses evidenced by faults mapped in the surface and thermal evolution on Mars.
J. F. Valdés-Galicia +1 more
doaj
Closed system of coupling effects in generalized thermo-elastoplasticity
International Journal of Applied Mechanics and Engineering, 2016 In this paper, the field equations of the generalized coupled thermoplasticity theory are derived using the postulates of classical thermodynamics of irreversible processses. Using the Legendre transformations two new thermodynamics potentials P and S
Z. Śloderbach
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Measuring wheel/rail contact stresses using ultrasound [PDF]
, 2004 The investigation of contact area and pressure distribution in a wheel/rail contact is essential information required in fatigue and wear calculations to determine design life, regrinding requirements, and maintenance schedules.
Bjorklund, S. +4 more
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