Results 111 to 120 of about 1,921,038 (288)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Stress-testing of the throat of a rocket's nozzle [PDF]
, 1969 Test motor in which high initial pressure can be reduced suddenly provides a method of testing stress effects in the throat of a rockets nozzle. Motors operating pressure is increased to aggravate tensile stresses in a submerged throat.
Estes, E. G.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Secondary stresses in trusses [PDF]
Structural analysis of fixed joint truss using method of secondary stresses and computer ...
Dwyer, T. J.
core +1 more source
Erosion of metals by multiple impacts with water [PDF]
, 1971 Investigation determines - relation between impact velocity and minimum number of impacts producing visible erosion, relation between high frequency fatigue stresses and number of cycles to failure, water-hammer stresses relation to high frequency ...
Rudy, S. L., Thiruvengadam, A.
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
FINITE ELEMENT MODELING OF RUTTING FOR FLEXIBLE PAVEMENT
Journal of Engineering and Sustainable Development, 2018 The aim of this research is studying the effect of base and subgrade layer local materials properties on the rutting damage of flexible pavement due to repeated traffic loading. The most roads in Baghdad city present severe rutting damage due to absence
Zainab Ahmed Alkaissi +1 more
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source