Results 221 to 230 of about 141,474 (306)

Contribution of α‐synuclein cytopathologies to distinct seeding of misfolded α‐synuclein

open access: yesBrain Pathology, EarlyView.
This study investigated whether brain regions with distinct predominance of α‐synuclein (αSyn) cytopathologies show different αSyn seeding patterns in multiple system atrophy (MSA) and Lewy body disease (LBD), using an interdisciplinary approach. High seeding activity is observed in regions with oligodendrocytic‐predominant αSyn pathology in MSA.
Ain Kim   +4 more
wiley   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

open access: yesBrain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li   +7 more
wiley   +1 more source

Comparison of automated and manual approaches for microglial quantification and classification: A focus on the HALO digital pathology platform

open access: yesBrain Pathology, EarlyView.
The Halo microglial activation module has not been formally validated in the literature. Comparison of this module with established methods revealed varied performance dependent on tissue thickness, highlighting the need for care to be taken when optimising image analysis parameters. Abstract Phenotypic changes in microglia have been linked to multiple
Laura M. Carr   +6 more
wiley   +1 more source

ontogenetic development of the dopaminergic function in the rat striatum.

open access: gold, 1980
Yasuyuki Nomura   +3 more
openalex   +1 more source

Psilocybin as a novel treatment for chronic pain

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey   +3 more
wiley   +1 more source

EFFECTS OF EXERCISE ON 3H-SPIROPERIDOL BINDING IN RAT STRIATUM

open access: bronze, 1983
P. E. Gilliam   +3 more
openalex   +1 more source

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