Results 251 to 260 of about 325,395 (379)

Temporal progression of pathological features in an α-synuclein overexpression model of Parkinson's disease. [PDF]

Brain Struct Funct
Vaquero-Rodríguez A, Razquin J, Murueta-Goyena A, Miguelez C, Ruíz-Ortega JÁ, Lafuente JV, Bengoetxea H, Ortuzar N.   +7 more
europepmc   +1 more source

Cortical and Striatal Functional Connectivity in Juvenile-Onset Huntington's Disease. [PDF]

Brain Sci
Barry A, Nopoulos PC.
europepmc   +1 more source

Pregnenolone Reduces L‐Dopa‐Induced Dyskinesias in Female Parkinsonian Monkeys

Movement Disorders, EarlyView.
Pregnenolone is the first neurosteroid synthesized from cholesterol in the brain. Ovariectomized female monkeys were tested as a model of women in menopause. They were lesioned with MPTP modeling Parkinson's disease and treated with levodopa (L‐dopa) to induce dyskinesias.
Mélanie Bourque, Marc Morissette, Marco Bortolato, Roberto Frau, Manolo Carta, Thérèse Di Paolo   +5 more
wiley   +1 more source

PKD1-mediated phosphorylation at dopamine D2 receptor serine 365 site in dorsal striatum underlies cocaine-induced locomotor hyperactivity. [PDF]

IBRO Neurosci Rep
Zhang X, Zhang Z, Wang Y, Sun L, Wang N.
europepmc   +1 more source

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, EarlyView.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

Mild Chronic Colitis Exacerbates Intracerebral Inflammation in Mice with Parkinson's Disease Through LRRK2-Mediated Regulation of NF-κB Activation and Inhibition of Nrf2. [PDF]

J Inflamm Res
Yang M, Ke L, Geng Y, Hu P, Qiu Y, Liu Z, Zhang X, Wan F, Jacob JA, Liao J.   +9 more
europepmc   +1 more source

Preproenkephalin messenger RNA—containing neurons in striatum of patients with symptomatic and presymptomatic huntington's disease: An in situ hybridization study [PDF]

, 1991
Roger L. Albin, Ying Qin, Anne B. Young, John B. Penney, Marie‐Françoise Chesselet   +4 more
openalex   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

White matter abnormalities of the frontal-striatal-thalamic circuit in individuals with attenuated positive symptom syndromes: a probabilistic tractography study. [PDF]

Schizophrenia (Heidelb)
Chen Z, Bo Q, Zhao L, Ding Y, Wang Y, Jiang Q, Li F, Zhou Y, Wang C.   +8 more
europepmc   +1 more source

Fast MR signal simulations of microvascular and diffusion contributions using histogram‐based approximation and recurrent neural networks

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose Accurate MR signal simulation, including microvascular structures and water diffusion, is crucial for MRI techniques like fMRI BOLD modeling and MR vascular Fingerprinting (MRF), which use susceptibility effects on MR signals for tissue characterization.
Thomas Coudert, Maitê Silva Martins Marçal, Aurélien Delphin, Antoine Barrier, Lila Cunge, Loïc Legris, Jan M. Warnking, Benjamin Lemasson, Emmanuel L. Barbier, Thomas Christen   +9 more
wiley   +1 more source