Results 51 to 60 of about 211,590 (248)
Standard Model EFTs via on-shell methods
Journal of High Energy Physics, 2021 We present the Standard Model Effective Field Theories (SMEFT) from purely on-shell arguments. Starting from few basics assumptions such as Poincaré invariance and locality, we classify all the renormalisable and non-renormalisable interactions at lowest
Manuel Accettulli Huber +1 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Two-dimensional SCFTs from matter-coupled $$7D~N=2$$ 7DN=2 gauged supergravity
European Physical Journal C: Particles and Fields, 2019 We study supersymmetric $$AdS_3\times M^4$$ AdS3×M4 solutions of $$N=2$$ N=2 gauged supergravity in seven dimensions coupled to three vector multiplets with $$SO(4)\sim SO(3)\times SO(3)$$ SO(4)∼SO(3)×SO(3) gauge group and $$M^4$$ M4 being a four ...
Parinya Karndumri, Patharadanai Nuchino
doaj +1 more source
Mechanical Engineering Journal, 2021 Recent years have witnessed attempts to employ a system with rigid and extremely flexible components (SREF), usually consisting of strings, membranes, and so on, to realize huge structures for spacecraft in orbit.
Shuntaro OOSHIMA, Yoshiki SUGAWARA
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Wave propagation in a non-uniform string
Revista Brasileira de Ensino de FísicaIn this article I present the behavior of the reflection and transmission coefficients of a pulse at a joint between two strings with mass densities μ1and μ2. The joint is made of a string segment with mass density varying linearly from μ1 to μ2. It will
Fernando Fuzinatto Dall'Agnol
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
, 2008 Latex, 17 pages including 6 figures Lecture at the Gursey Memorial Conference I, Strings and Symmetries, June ...
openaire +2 more sources