Results 121 to 130 of about 207,701 (143)

Yeast has a true stringent response

Nature, 1978
IN bacteria there is a coordinate regulation of the synthesis of ribosomal RNA and ribosomal protein1. This is most evident from studies of the rates of synthesis of ribosomal components as a function of the growth rate of the cell2,3. Another example is the ‘stringent response’, in which cells deprived of an essential amino acid shut down the ...
J R, Warner, C, Gorenstein
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Revisiting the stringent response, ppGpp and starvation signaling

Current Opinion in Microbiology, 2001
Microbial adaptation to environmental stress plays an important role in survival. It is necessary to understand the mechanisms underlying the survival of microbes under stress, as they may eventually aid in the successful control of the growth and persistence of these organisms.
Chatterji, Dipankar, Ojha, Anil Kumar
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Mammalian cells do not have a stringent response

Journal of Cellular Physiology, 1980
AbstractA key attribute of the stringent response of bacteria is the rapid inhibition of ribosomal RNA synthesis mediated by unusual nucleotides in response to uncharged tRNA. The question as to whether mammalian cells show a stringent response analogous to that of bacteria was critically tested by the effective rapid amino acid starvation of both ...
J W, Pollard, T, Lam, C P, Stanners
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Inefficiency of the stringent response in the fungus Mucor

Biochemical and Biophysical Research Communications, 1980
Abstract Removal of a required amino acid from the growth medium or addition of cycloheximide caused an immediate stoppage of growth and protein synthesis in the fungus Mucor racemosus . However, RNA synthesis persisted for several hours at rates that only gradually decreased under the same circumstances. An analysis of the major classes of RNA
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The Stringent Response—21 Years On

1974
During normal growth, bacteria synthesize no more ribosomes than can be engaged with high efficiency in protein synthesis (1). The molecular mechanism maintaining this fine balance is clearly of crucial importance in determining the growth characteristics of the cell.
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Structural Insights into the Stringent Response

Science's STKE, 2004
The stringent response allows bacteria to survive conditions of amino acid starvation through regulation of transcription by derivatives of guanosine triphosphate or guanosine diphosphate collectively called alarmone or ppGpp [for guanosine 3′-diphosphate 5′-triphosphate or guanosine 3′,5′-bis(diphosphate)].
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Impact of the plastidial stringent response in plant growth and stress responses

Nature Plants, 2015
The regulatory nucleotide guanosine 5'-diphosphate 3'-diphosphate (ppGpp), which was originally identified in Escherichia coli, controls the expression of a large gene set and many enzyme activities. The ppGpp-dependent control of cell activities is referred to as the stringent response.
Mikika Maekawa, Rina Honoki, Yuta Ihara, Ryoichi Sato, Akira Oikawa, Yuri Kanno, Hiroyuki Ohta, Mitsunori Seo, Kazuki Saito, Shinji Masuda   +9 more
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Induction of Stringent Response by Streptomycin in Bacillus subtilis Cells

The Journal of Biochemistry, 1985
A stringent response was induced in Bacillus subtilis vegetative cells by streptomycin. This was confirmed as follows: In B. subtilis stringent cells (BR16S), stable RNA synthesis was repressed, and pppGpp and ppGpp were transiently synthesized in the presence of required amino acids and streptomycin.
K, Ikehara, E, Kamitani, C, Koarata, A, Ogura   +3 more
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ppGpp: stringent response and survival.

Journal of microbiology (Seoul, Korea), 2006
Adaptation to any undesirable change in the environment dictates the survivability of many microorganisms, with such changes generating a quick and suitable response, which guides the physiology of bacteria. During nutritional deprivation, bacteria show a stringent response, as characterized by the accumulation of (p)ppGpp, resulting in the repression ...
Jain, Vikas, Kumar, Manish, Chatterji, Dipankar   +2 more
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Uncharged tRNA, protein synthesis, and the bacterial stringent response

Molecular Microbiology, 1990
SummaryUncharged tRNA has been shown in vivo to have an active role both in the stringent response, and in modulating the rate of translational elongation. Both of these effects appear to be mediated by codon–anticodon interactions on the ribosome.
E, Goldman, H, Jakubowski
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