Results 241 to 250 of about 212,665 (269)
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Mammalian cells do not have a stringent response
Journal of Cellular Physiology, 1980AbstractA key attribute of the stringent response of bacteria is the rapid inhibition of ribosomal RNA synthesis mediated by unusual nucleotides in response to uncharged tRNA. The question as to whether mammalian cells show a stringent response analogous to that of bacteria was critically tested by the effective rapid amino acid starvation of both ...
J W, Pollard, T, Lam, C P, Stanners
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Inefficiency of the stringent response in the fungus Mucor
Biochemical and Biophysical Research Communications, 1980Abstract Removal of a required amino acid from the growth medium or addition of cycloheximide caused an immediate stoppage of growth and protein synthesis in the fungus Mucor racemosus . However, RNA synthesis persisted for several hours at rates that only gradually decreased under the same circumstances. An analysis of the major classes of RNA
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The Stringent Response—21 Years On
1974During normal growth, bacteria synthesize no more ribosomes than can be engaged with high efficiency in protein synthesis (1). The molecular mechanism maintaining this fine balance is clearly of crucial importance in determining the growth characteristics of the cell.
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Impact of the plastidial stringent response in plant growth and stress responses
Nature Plants, 2015The regulatory nucleotide guanosine 5'-diphosphate 3'-diphosphate (ppGpp), which was originally identified in Escherichia coli, controls the expression of a large gene set and many enzyme activities. The ppGpp-dependent control of cell activities is referred to as the stringent response.
Mikika Maekawa +9 more
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Structural Insights into the Stringent Response
Science's STKE, 2004The stringent response allows bacteria to survive conditions of amino acid starvation through regulation of transcription by derivatives of guanosine triphosphate or guanosine diphosphate collectively called alarmone or ppGpp [for guanosine 3′-diphosphate 5′-triphosphate or guanosine 3′,5′-bis(diphosphate)].
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Uncharged tRNA, protein synthesis, and the bacterial stringent response
Molecular Microbiology, 1990SummaryUncharged tRNA has been shown in vivo to have an active role both in the stringent response, and in modulating the rate of translational elongation. Both of these effects appear to be mediated by codon–anticodon interactions on the ribosome.
E, Goldman, H, Jakubowski
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Induction of Stringent Response by Streptomycin in Bacillus subtilis Cells
The Journal of Biochemistry, 1985A stringent response was induced in Bacillus subtilis vegetative cells by streptomycin. This was confirmed as follows: In B. subtilis stringent cells (BR16S), stable RNA synthesis was repressed, and pppGpp and ppGpp were transiently synthesized in the presence of required amino acids and streptomycin.
K, Ikehara +3 more
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Regulation of mitochondrial transcription during the stringent response in yeast
Current Genetics, 1992In yeast (S. cerevisiae) the stringent response is known to include rapid, selective, and severe transcriptional curtailment for genes specifying cytoplasmic rRNAs and r-proteins. We have shown that transcription of the mitochondrial 21S rRNA gene is also congruently and selectively curtailed during the yeast stringent response.
R, Cantwell, C M, McEntee, A P, Hudson
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The Stringent Response of Salmonella Typhimurium
2021Bacteria inhabit diverse environmental niches and consequently, must modulate their metabolism to adapt to stress. The nucleotide second messengers guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) (collectively referred to as (p)ppGpp) are essential for survival during nutrient starvation.
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