Results 141 to 150 of about 29,127 (251)

Proteomic Profiling Captures Residual Cardiovascular Risk Beyond the PREVENT Model in Individuals With Cardiovascular–Kidney–Metabolic Syndrome Stages 2–3

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Cardiovascular–kidney–metabolic (CKM) syndrome reflects complex pathobiological interactions among metabolic disorders, kidney injury, and cardiovascular disease (CVD). Stages 2 and 3 represent critical phases of disease progression characterised by high pathological heterogeneity.
Xuefei Han   +4 more
wiley   +1 more source

Trends in Second‐Line Initiations and Treatment Outcomes Across Age and Frailty Groups in People With Type 2 Diabetes: UK Population‐Based Study, 2019–2024

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess contemporary UK trends in second‐line treatment initiations and outcomes across age‐and‐frailty groups in people with type 2 diabetes (T2D). Materials and Methods We studied 117 046 UK adults with T2D initiating second‐line therapy between 2019–2024 (Clinical Practice Research Datalink).
M. M. Dinsdale   +11 more
wiley   +1 more source

Diabetic Corneal Neuropathy as a Window Into Diabetic Foot Risk: A Large‐Scale Association Study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the association between diabetic corneal neuropathy and diabetic foot risk by examining corneal nerve features, clinical characteristics, and tear mediators in patients with different diabetic foot risk categories. Methods In this cross‐sectional study, 710 participants underwent diabetic foot examination, in vivo confocal ...
Chang Liu   +12 more
wiley   +1 more source

Is There a Difference in Occurrence of Complications Between Adults With Hemoglobin SS and Hemoglobin SC Disease: An Extended Systematic Review

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is characterized by both acute and chronic complications. The clinical manifestation of these complications differs between genotypes. Given the large amount of research already published, this systematic review aims to offer a complete overview of types of sickle cell complications between adults in the most common ...
Martijn van der Meer   +3 more
wiley   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

open access: yesThe FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi   +12 more
wiley   +1 more source

Neuroimaging biomarkers in migraine with aura mimicking stroke: A qualitative and quantitative analysis of perfusion CT alterations

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary Migraine with aura can mimic a stroke, making diagnosis difficult and sometimes leading to unnecessary treatment in the acute setting. We found that some patients with migraine with aura show characteristic changes on brain perfusion CT scans, particularly in men and those with speech symptoms, which can be better detected using ...
Lucía Gómez Martín de la Escalera   +8 more
wiley   +1 more source

Prospective Trial of Radiofrequency Catheter Ablation of High Dominant Frequencies After Pulmonary Vein Isolation in Non‐Paroxysmal Atrial Fibrillation (PAD‐AF Trial): A Multicenter, Randomized Clinical Trial

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
In persistent AF, adjunctive dominant frequency‐guided ablation after pulmonary vein isolation did not significantly improve outcomes. Limited overlap between high‐frequency sites and low‐voltage areas suggests functional–structural dissociation, while right atrial low‐voltage burden predicts recurrence.
Koji Kumagai   +10 more
wiley   +1 more source

Late-onset mitochondrial encephalomyopathy with lactic acid and stroke-like episodes (MELAS), defining symptomology

open access: yesMolecular Genetics and Metabolism Reports, 2017
J. Gass, H.K Atwal, P.S. Atwal
doaj   +1 more source

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