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Mitochondrial Stroke-Like Episodes: The Search for New Therapies
Pharmacological Research, 2022 A mitochondrial stroke-like event is an evolving subacute neurological syndrome linked to seizure activity and focal metabolic brain derangement in a genetically determined mitochondrial disorder. The acronym "MELAS" (mitochondrial encephalopathy associated with lactic acidosis and stroke-like lesions) identifies subjects with molecular, biochemical ...
Gabriele Siciliano +2 more
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MRI Features of Stroke-Like Episodes in Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-Like Episodes [PDF]
Frontiers in Neurology, 2022 Mitochondrial myopathy encephalopathy lactic acidosis and stroke-like episodes (MELAS) is an important cause of stroke-mimicking diseases that predominantly affect patients before 40 years of age. MELAS results from gene mutations in either mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) responsible for the wide spectrum of clinical symptoms and ...
Weiqin Cheng, Yuting Zhang, Ling He
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Neuroimaging of Stroke-Like Episodes in MELAS
Brain and Development, 2011Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) shows sudden neurological deficits that are called 'stroke-like episodes'. With regard to the pathophysiology of stroke-like episodes, so-called mitochondrial angiopathy and cytopathy theories have been proposed, but the subject is still controversial.
Hiromichi Itô, Shoji Kagami
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Journal of Stroke and Cerebrovascular Diseases, 2023
A 40-year-old man with sensorineural hearing loss and diabetes mellitus was hospitalized with acute-onset impaired consciousness and clumsiness in his left hand. He had been taking metformin for 4 months. A neurological examination revealed confusion and weakness in the left upper limb.
Hidefumi Ito +2 more
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A 40-year-old man with sensorineural hearing loss and diabetes mellitus was hospitalized with acute-onset impaired consciousness and clumsiness in his left hand. He had been taking metformin for 4 months. A neurological examination revealed confusion and weakness in the left upper limb.
Hidefumi Ito +2 more
exaly +3 more sources
Stroke-like episodes in adult mitochondrial disease
2023Stroke-like episode is a paroxysmal neurological manifestation which affects a specific group of patients with mitochondrial disease. Focal-onset seizures, encephalopathy, and visual disturbances are prominent findings associated with stroke-like episodes, with a predilection for the posterior cerebral cortex.
Ng YS, Gorman GS
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Stroke-like episodes, peri-episodic seizures, and MELAS mutations
European Journal of Paediatric Neurology, 2016Stroke-like episodes (SLEs) are a hallmark of various mitochondrial disorders, in particular MELAS syndrome. SLEs manifest with vasogenic oedema (DWI and ADC hyperintensity) or partial cytotoxic oedema (DWI hyperintensity, ADC hypointensity) in the acute and subacute stage, and with gyriform T1-hyperintensity (cortical necrosis) in the chronic stage ...
Josef, Finsterer, Salma Majid, Wakil
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Management of mitochondrial stroke‐like‐episodes
European Journal of Neurology, 2009Aim of this review is to discuss recent findings concerning the management of stroke‐like episodes (SLEs) in patients with mitochondrial disorders (MIDs). Various databases were searched for appropriate literature. SLEs are a dominant feature of MIDs and occur most frequently in MELAS‐syndrome, less frequently in MERRF‐syndrome, Kearns‐Sayre‐syndrome ...
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