Results 151 to 160 of about 5,540,038 (306)

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science
To address the key challenges in ischemic stroke treatment—inadequate multi‐target intervention, low blood‐brain barrier (BBB) permeability, and lack of lesion‐specific drug release—we developed an innovative pH/ROS dual‐responsive lipid‐nanozyme system,
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
doaj   +1 more source

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Ischemic stroke as a presenting feature of neurosyphilis in an immunocompetent adult and attained complete recovery following treatment: a case report and review of the literature

Journal of Medical Case Reports
Background Neurosyphilis typically presents with nonspecific symptoms such as behavioral changes or cognitive impairment, rather than an initial stroke.
Elsah Tegene Asefa, Tamirat Godebo Woyimo, Yosef Bekele Bonsa, Addisalem Gebre Silase   +3 more
doaj   +1 more source

DeepISLES: a clinically validated ischemic stroke segmentation model from the ISLES'22 challenge

Nature Communications
Diffusion-weighted MRI is critical for diagnosing and managing ischemic stroke, but variability in images and disease presentation limits the generalizability of AI algorithms.
Ezequiel de la Rosa, Mauricio Reyes, Sook-Lei Liew, Alexandre Hutton, Roland Wiest, Johannes Kaesmacher, Uta Hanning, Arsany Hakim, Richard Zubal, Waldo Valenzuela, David Robben, Diana M. Sima, Vincenzo Anania, Arne Brys, James A. Meakin, Anne Mickan, Gabriel Broocks, Christian Heitkamp, Shengbo Gao, Kongming Liang, Ziji Zhang, Md Mahfuzur Rahman Siddiquee, Andriy Myronenko, Pooya Ashtari, Sabine Van Huffel, Hyunsu Jeong, Chiho Yoon, Chulhong Kim, Jiayu Huo, Sebastien Ourselin, Rachel Sparks, Albert Clèrigues, Arnau Oliver, Xavier Lladó, Liam Chalcroft, Ioannis Pappas, Jeroen Bertels, Ewout Heylen, Juliette Moreau, Nima Hatami, Carole Frindel, Abdul Qayyum, Moona Mazher, Domenec Puig, Shao-Chieh Lin, Chun-Jung Juan, Tianxi Hu, Lyndon Boone, Maged Goubran, Yi-Jui Liu, Susanne Wegener, Florian Kofler, Ivan Ezhov, Suprosanna Shit, Moritz R. Hernandez Petzsche, Michael Müller, Bjoern Menze, Jan S. Kirschke, Benedikt Wiestler   +58 more
doaj   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Rising Use of Reconstructive Cartilage Procedures of the Knee With Persistently Low Surgical Complication Rates Based on the American College of Surgeons National Surgical Quality Improvement Program

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To determine current treatments used for chondral defects of the knee, to analyze complications, and to identify risk factors for adverse events. Methods In this retrospective database study, the American College of Surgeons National Surgery Quality Improvement Program database (2010‐2023) was searched using Current Procedural Terminology codes
Braeden R. Gooch, Grayson M. Talaski, Shahab Yazdanpanah, Charles R. Reiter, Conor N. O’Neill, Omar A. Protzuk, J. Brett Goodloe, Christian Lattermann, Annuziato N. Amendola   +8 more
wiley   +1 more source

Evaluating discrepancies between high‐yield neuroscience conditions in preclerkship medical education and national clinical incidence

Anatomical Sciences Education, EarlyView.
Abstract Medical education must balance foundational science with clinical relevance. Increasing emphasis on standardized assessments has led to prioritization of “high‐yield” conditions—those most likely to be assessed. Subsequently, educators and students often prioritize these conditions.
Kathryn Veazey, Oheneba Boadum
wiley   +1 more source

Cerebellar Stroke-like Lesions?

Internal Medicine, 2019
openaire   +3 more sources

Clinical neuroanatomy teaching at Peking University Health Science Center: Evolution, current practice, and future direction

Anatomical Sciences Education, EarlyView.
Abstract Neuroanatomy has been considered one of the most challenging subjects in medical education, often leading to “neurophobia” and discouraging students from pursuing neurological specialties. At PKUHSC, the curriculum has evolved from a traditional, discipline‐based model to a technology‐enhanced, integrated “Nervous System” module for ...
Xuan Fang, Man Li, Xiaodan Hu, Chang Su, Shan Ye, Xianzhong Shi, Xiaomei Yang, Changman Zhou, Weiguang Zhang, Chunhua Chen   +9 more
wiley   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source