Results 161 to 170 of about 5,540,038 (306)

Fibroproliferative Remodeling of Immune‐Vascular Co‐Culture Spheroid Models in Response to Atherogenic Stimulation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cell‐based models are highly valuable platforms for preclinical studies of atherosclerosis, offering controllable environments to investigate disease mechanisms. Three‐dimensional (3D) spheroids, a class of cell‐based models, enable the study of atherosclerotic disease phenomena under physiologically relevant yet controlled conditions. In this
Ibukunoluwa Naiyeju, Stephanie Lehoux, Maryam Tabrizian   +2 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Stroke-like lesion and status epilepticus in a child with <i>NARS2</i>-related combined oxidative phosphorylation deficiency 24. [PDF]

Front Neurol
Su S, Hu W, Liu Y, Lang Q, Zhang H.
europepmc   +1 more source

Harnessing bacterial extracellular vesicles for bone and cartilage organoids

BMEMat, EarlyView.
This review presents bacterial extracellular vesicles (BEVs) as programmable bioactive regulators for bone and cartilage organoids by delivering functional cargos that modulate skeletal remodeling. It highlights key engineering strategies and future directions to advance next‐generation organoid models for bone aging related diseases.
Han Liu, Xukun Lv, Ting Cheng, Lei Yan, Yuxiao Lai, Keying Guo, Yingying Jing, Hao Shen, Jiacan Su   +8 more
wiley   +1 more source

Stroke Clinician Interviews the Co-Founders of Phagenesis

Stroke Clinician recently had the opportunity to interview Drs. Shaheen Hamdy, Chief Scientific Officer and Conor Mulrooney, Chief Operating Officer of Phagenesis. Drs.
Clinician, Stroke
core   +1 more source

Restoring joint homeostasis: A dynamically adaptive meniscal scaffold prevents osteoarthritis by replicating native biomechanics

BMEMat, EarlyView.
This work establishes a paradigm shift from static structural mimicry to dynamic functional replication. By restoring the native “compression‐to‐tension” mechanism, the scaffold ensures robust mechanical stability and superior chondroprotection.
Wan Li, Moran Huang, Dongsen Jia, Yongjie Jiao, Jize Dong, Fujun Wang, Xinhou Wang, Jiwu Chen, Malcolm Xing, Lu Wang, Chaojing Li   +10 more
wiley   +1 more source

From muscle fibres to muscle gears: how dynamic fascicle orientation and shape change impact skeletal muscle function

Biological Reviews, EarlyView.
ABSTRACT Skeletal muscle architectural design strongly affects force‐generating capacity and excursion range, and its functional importance to animal and human movement is well founded. Traditionally, this ‘structure–function relation’ has been inferred from architecture measurements with muscles at rest (from anatomical dissections or medical imaging ...
Matheus D. Pinto, James M. Wakeling, Javier A. Almonacid, Anthony J. Blazevich   +3 more
wiley   +1 more source

Post-Stroke Olfactory Dysfunction: Network Mechanisms, Clinical Consequences, and Rehabilitation. [PDF]

Brain Sci
Heinbockel T, Virdi G, Shannon L, Nandi S.   +3 more
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source