Results 251 to 260 of about 313,405 (295)

Platelets and Stromal Cell-Derived Factor-1 in Progenitor Cell Recruitment

Seminars in Thrombosis and Hemostasis, 2007
Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that binds to its sole counterreceptor, CXCR4. It is well reported that the SDF-1/CXCR4 signaling pathway is of vital importance to human development and to various pathophysiological phenomena, including hematopoiesis, angiogenesis, atherosclerosis, cancer growth, metastasis, and human ...
Konstantinos, Stellos, Meinrad, Gawaz
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Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma

Cancer Letters, 2005
Stromal cell-Derived Factor-1 (SDF-1, CXCL12) is one the ELR- CXC angiogenic chemokines. It contributes to hematopoiesis and lymphocyte trafficking. SDF-1 and its exclusive receptor, CXCR4, are reported to play important roles in tumor growth, angiogenesis and metastasis of different types of tumors such as breast, lung, prostate and pancreatic cancers.
Mahboobeh, Razmkhah, Abdul-Rasoul, Talei, Mehrnoosh, Doroudchi, Tahereh, Khalili-Azad, Abbas, Ghaderi   +4 more
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Stromal Cell Derived Factor-1 (CXCL12) Chemokine Gene Variant in Myeloid Leukemias

Clinical Laboratory, 2014
Acute and chronic myeloid leukemia are initiated and sustained by a small, self-renewing population of leukemic stem cells, which produce progeny of a heterogeneous population of progenitor cells. CXCL12, a chemokine abundantly produced by the bone marrow microenvironment, and its receptor CXCR4 have crucial roles in malignant cell trafficking.
Hoda Mohamed A, El-Ghany, Zainab Ali, El-Saadany, Nevien Mohamed, Bahaa, Noha Yehia, Ibrahim, Salwa Mahmoud, Hussien   +4 more
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Neutrophil Homeostasis: A New Role for Stromal Cell–Derived Factor-1

Immunologic Research, 2005
Neutrophils are a key component of the innate immune response and a major contributor to inflammation. Accordingly, their number in the blood is tightly controlled. Neutrophils are normally produced exclusively in the bone marrow, and their release into the blood is tightly regulated to maintain homeostatic levels in the blood.
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Exogenous stromal cell-derived factor-1 induces modest leukocyte recruitment in vivo

American Journal of Physiology-Heart and Circulatory Physiology, 2008
Stromal cell-derived factor-1 (SDF-1; CXCL12), a CXC chemokine, has been found to be involved in inflammation models in vivo and in cell adhesion, migration, and chemotaxis in vitro. This study aimed to determine whether exogenous SDF-1 induces leukocyte recruitment in mice.
Steven M, Kerfoot, Graciela, Andonegui, Claudine S, Bonder, Lixin, Liu   +3 more
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Biphasic expression of stromal cell-derived factor-1 during human wound healing

British Journal of Dermatology, 2007
Chemokines tightly regulate the spatial and temporal infiltration of invading leucocyte subsets during wound healing. Stromal cell-derived factor-1 (SDF-1/CXCL12) is a homeostatic chemokine with multiple functions; its role during cutaneous wound healing, however, needs to be explored.To elucidate expression of the multifunctional CXC chemokine SDF-1 ...
A, Toksoy, V, Müller, R, Gillitzer, M, Goebeler   +3 more
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Stromal Cell-Derived Factor 1 (SDF-1) Signaling and Tissue Homeostasis

2019
Stromal cell-derived factor 1 (SDF-1) or C-X-C motif chemokine 12 (CXCL12) is a highly potent chemoattractant and paracrine protein with critical roles in embryogenesis and hematopoiesis, as well as postnatal tissue repair and regeneration. It acts through the chemokine receptor 4 (CXCR4) and CXCR7 receptors to mediate chemotactic processes including ...
Zeshaan N. Maan, Mimi R. Borrelli, Khosrow Siamak Houschyar, Geoffrey C. Gurtner   +3 more
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Increase of circulating stromal cell-derived factor-1 in heart failure patients

Herz, 2014
The role of circulating stromal cell-derived factor-1 (SDF-1) in heart failure (HF) has not been defined. The aim of this study was to examine the circulating SDF-1 levels in hospitalized heart failure (HHF) patients.Circulating SDF-1 and other clinical variables, including N-terminal pro-brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP),
K, Liu, S, Yang, M, Hou, T, Chen, J, Liu, B, Yu   +5 more
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Epiphysiodesis with Infusion of Stromal Cell-Derived Factor-1 in Rabbit Growth Plates

The Journal of Bone & Joint Surgery, 2007
The mechanism of physeal closure is poorly understood, although both mechanical and biological factors may play a role in the process. In this study, we evaluated the effect of the application of a chemokine stromal cell-derived factor-1 (SDF-1) to rabbit physes in vivo with regard to growth inhibition.A continuous infusion system consisting of a ...
Mark C, Lee, Adam D, Bier, Florian, Nickisch, Craig P, Eberson, Michael G, Ehrlich, Qian, Chen   +5 more
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Platelet expression of stromal-cell-derived factor-1 (SDF-1): An indicator for ACS?

International Journal of Cardiology, 2013
Acute coronary syndrome (ACS) along with myocardial ischemic injury are the leading causes for chest pain. Platelet surface expression of stromal-cell-derived factor-1 (SDF-1) is enhanced during ischemic events and may play an important role in trafficking hematopoietic progenitor cells for tissue regeneration and neovascularization.
Wurster, Thomas, Stellos, Konstantinos, Haap, Michael, Seizer, Peter, Geisler, Tobias, Otton, James, Indermuehle, Andreas, Ishida, Masaki, Schuster, Andreas, Nagel, Eike, Gawaz, Meinrad, Bigalke, Boris   +11 more
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