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Gastrointestinal stromal tumors
Abdominal Imaging, 2006We reviewed radiologic features of gastrointestinal stromal tumors (GISTs) and correlated them with clinical and pathologic findings.We investigated a series of 39 c-Kit-positive GISTs. Clinical and radiologic findings and management of these patients were recorded.Twenty women and 19 men (mean age 64 years) had histologically proved GIST.
A, Darnell +8 more
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Gastrointestinal stromal tumor
Surgical Oncology, 2008Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. These form a distinct category of tumors characterized by oncogenic mutations of the KIT receptor tyrosine kinase in a majority of patients. KIT is used not only for diagnosis but also for targeted therapy of GISTs.
Puneet, Gupta +2 more
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Gastrointestinal Stromal Tumors
Hematology/Oncology Clinics of North America, 2005Gastrointestinal stromal tumors (GISTs) are identified pathologically by the expression of KIT. The management of GISTs has been altered significantly by the development of imatinib mesylate, a tyrosine kinase inhibitor with activity against KIT and platelet-derived growth factor receptors.
Margaret, von Mehren, James C, Watson
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Gastrointestinal stromal tumors
Virchows Archiv, 2010Gastrointestinal stromal tumors (GISTs) have emerged from being poorly defined, treatment-resistant tumors to a well-recognized, well-understood, and treatable tumor entity within only one decade. The understanding of GIST biology has made this tumor a paradigm for molecularly targeted therapy in solid tumors and provides informative insights into the ...
Bernadette, Liegl-Atzwanger +2 more
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Gastrointestinal Endoscopy, 2003
GI stromal tumors (GIST) previously were thought to represent smooth muscle tumors of the GI tract and were formerly classified as leiomyomas and leiomyosarcomas. Within the past decade, there have been several major scientific advances in the understanding of these tumors, their possible origin, and pathogenesis, and this in turn has greatly impacted ...
Raquel E, Davila, Douglas O, Faigel
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GI stromal tumors (GIST) previously were thought to represent smooth muscle tumors of the GI tract and were formerly classified as leiomyomas and leiomyosarcomas. Within the past decade, there have been several major scientific advances in the understanding of these tumors, their possible origin, and pathogenesis, and this in turn has greatly impacted ...
Raquel E, Davila, Douglas O, Faigel
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The American Surgeon, 2000
Gastric stromal tumors display a bewildering array of immunohistological and ultrastructural features as well as variable biological behavior. These tumors are rare as compared with ones that arise from the gastric epithelium. Moreover, they have been the subjects of controversy because of their uncertain histogenesis.
V S, Parithivel +7 more
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Gastric stromal tumors display a bewildering array of immunohistological and ultrastructural features as well as variable biological behavior. These tumors are rare as compared with ones that arise from the gastric epithelium. Moreover, they have been the subjects of controversy because of their uncertain histogenesis.
V S, Parithivel +7 more
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Gastrointestinal Stromal Tumors
Current Oncology ReportsThis review aims to outline the current understanding of the molecular drivers and treatment paradigms of gastrointestinal stromal tumors, with a focus on recent developments in treatment in the advanced disease setting.There have been recent advancements in our understanding of the molecular biology of gastrointestinal stromal tumors, including the ...
Gal, Strauss, Suzanne, George
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Gastrointestinal Stromal Tumors
American Journal of Therapeutics, 2016The understanding of aberrant molecular pathways that result in gastrointestinal stromal tumors (GISTs) and the rapid development of molecular therapies that target these pathways represent one of the great milestones in translational oncology.
Aakanksha Prasad, Asija +3 more
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Gastrointestinal Stromal Tumors and Neuroendocrine Tumors
Seminars in Oncology Nursing, 2009Patients with rare gastrointestinal (GI) malignancies can exhibit unique objective and subjective manifestations. This article is a primer for the fundamental understanding of some of these diseases, namely gastrointestinal stromal tumors (GIST) and gastroenteropancreatic neuroendocrine tumors (NET) and therapeutic strategies.Epidemiologic data ...
Carolyn, Grande, Daniel G, Haller
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