Results 71 to 80 of about 662,923 (221)

Origin, variability and age of biomass burning plumes intercepted during BORTAS-B [PDF]

Atmospheric Chemistry and Physics, 2014
We use the GEOS-Chem atmospheric chemistry transport model to interpret aircraft measurements of carbon monoxide (CO) in biomass burning outflow taken during the 2011 BORTAS-B campaign over eastern Canada.
D. P. Finch, P. I. Palmer, M. Parrington
doaj   +1 more source

Nonlocal Scalar Quantum Field Theory: Functional Integration, Basis Functions Representation and Strong Coupling Expansion

, 2019
Nonlocal QFT of one-component scalar field $\varphi$ in $D$-dimensional Euclidean spacetime is considered. The generating functional (GF) of complete Green functions $\mathcal{Z}$ as a functional of external source $j$, coupling constant $g$, and spatial
Bernard, M., Guskov, V. A., Ivanov, M. G., Kalugin, A. E., Ogarkov, S. L.   +4 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Formal software measurements for object-oriented business models. [PDF]

This paper presents a set of metrics and pseudo-metrics for the measurement of conceptual distances in M.E.R.O.D.E. business models. The measures are developed and validated using measure and measurement theory.
Dedene, Guido, Poels, Geert
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Responses of Macroinvertebrate Communities to Heterogeneity Among Typical Reaches in the Upper Yangtze River

Ecology and Evolution
Benthic macroinvertebrates are important indicators of river ecosystem health, and their spatial distribution is highly sensitive to environmental heterogeneity. In large mountainous rivers characterized by complex geomorphology and strong hydrodynamics,
Yang Wei, Wang Si‐Yuan, Zhang Xian‐Bing, Zhang Yang‐Chun, Chen Zi‐Wei, Yang Zhong‐Chao, Yang Sheng‐Fa, Chen Qi‐Liang, Xie Jia‐Hui, Tan Li‐Wei   +9 more
doaj   +1 more source

Generalised hyperbolicity in spacetimes with string-like singularities

, 2016
In this paper we present well-posedness results of the wave equation in $H^{1}$ for spacetimes that contain string-like singularities. These results extend a framework able to characterise gravitational singularities as obstruction to the dynamics of ...
Sanchez, Yafet Sanchez, Vickers, James A.   +1 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source