Results 101 to 110 of about 544,762 (274)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Product version of reciprocal degree distance of composite graphs

Communications in Combinatorics and Optimization, 2018
In this paper‎, ‎we present the upper bounds for the product version of reciprocal degree distance of the tensor product‎, ‎join and strong product of two graphs in terms of other graph invariants including the Harary index and Zagreb indices‎.
K‎. ‎Pattabiraman
doaj   +1 more source

The geodetic number of strong product graphs

Discussiones Mathematicae Graph Theory, 2010
For two vertices u and v of a connected graph G, the set IG[u; v] consists of all those vertices lying on u v geodesics in G. Given a set S of vertices of G, the union of all sets IG[u; v] for u; v 2 S is denoted by IG[S]. A set S V (G) is a geodetic set if IG[S] = V (G) and the minimum cardinality of a geodetic set is its geodetic number g(G) of G ...
A.P. Santhakumaran, S.V. Ullas Chandran
openaire   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Sharp Upper Bounds for Generalized Edge-Connectivity of Product Graphs

Discussiones Mathematicae Graph Theory, 2016
The generalized k-connectivity κk(G) of a graph G was introduced by Hager in 1985. As a natural counterpart of this concept, Li et al. in 2011 introduced the concept of generalized k-edge-connectivity which is defined as λk(G) = min{λ(S) : S ⊆ V (G) and |
Sun Yuefang
doaj   +1 more source

Product Operations on Pythagorean Co-Neutrosophic Graphs and its Application [PDF]

Neutrosophic Sets and Systems
Pythagorean Co-Neutrosophic Graphs (PyCNGs) have newly emerged after the foundation of Pythagorean fuzzy graph and Co-neutrosophic graphs, where the membership of indeterminacy(uncertain) is independent and membership of truth(existence) & false(non ...
G. Vetrivel, M. Mullai , G. Rajchakit
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

1-factorisation of the Composition of Regular Graphs

, 1983
1-factorability of the composition of graphs is studied. The followings sufficient conditions are proved: $G[H]$ is 1-factorable if $G$ and $H$ are regular and at least one of the following holds: (i) Graphs $G$ and $H$ both contain a 1-factor, (ii) $G ...
Mohar, B., Pisanski, T., Shawe-Taylor, J.   +2 more
core